| Gene Symbol |
Kcnk2
|
| Entrez Gene |
16526
|
| Alt Symbol |
A430027H14Rik, AI848635, TREK-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, subfamily K, member 2
|
| Other Description |
TREK-1 K(+) channel subunit|outward rectifying potassium channel protein TREK-1|potassium channel subfamily K member 2|two pore potassium channel TPKC1
|
| Swissprots |
Q4VQI2 P97438
|
| Accessions |
EDL13030 P97438 AK080342 AK138427 BAE23658 AK140716 BAE24455 AK164197 AY736359 AAV48996 BC062094 AAH62094 BE654630 BF472201 BM945997 BQ174170 BQ572833 BY004036 BY252821 BY267214 BY276415 BY276551 CJ163788 CN528767 CX211547 U73488 AAC53005 XM_006497121 XP_006497184 XM_006497122 XP_006497185 NM_001159850 NP_001153322 NM_001281847 NP_001268776 NM_001281848 NP_001268777 NM_010607 NP_034737
|
| Function |
Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. {ECO:0000250}.
|
| Subcellular Location |
Isoform 1: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
High expression in brain and lung. Also detected in kidney, heart and skeletal muscle. Not detected in liver. In the brain, highest expression in olfactory bulb, hippocampus and cerebellum. {ECO:0000269|PubMed:9003761}.
|
| Top Pathways |
Gastric acid secretion
|