Gene Symbol | Kcnk2 |
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Entrez Gene | 16526 |
Alt Symbol | A430027H14Rik, AI848635, TREK-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | potassium channel, subfamily K, member 2 |
Other Description | TREK-1 K(+) channel subunit|outward rectifying potassium channel protein TREK-1|potassium channel subfamily K member 2|two pore potassium channel TPKC1 |
Swissprots | Q4VQI2 P97438 |
Accessions | EDL13030 P97438 AK080342 AK138427 BAE23658 AK140716 BAE24455 AK164197 AY736359 AAV48996 BC062094 AAH62094 BE654630 BF472201 BM945997 BQ174170 BQ572833 BY004036 BY252821 BY267214 BY276415 BY276551 CJ163788 CN528767 CX211547 U73488 AAC53005 XM_006497121 XP_006497184 XM_006497122 XP_006497185 NM_001159850 NP_001153322 NM_001281847 NP_001268776 NM_001281848 NP_001268777 NM_010607 NP_034737 |
Function | Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. {ECO:0000250}. |
Subcellular Location | Isoform 1: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | High expression in brain and lung. Also detected in kidney, heart and skeletal muscle. Not detected in liver. In the brain, highest expression in olfactory bulb, hippocampus and cerebellum. {ECO:0000269|PubMed:9003761}. |
Top Pathways | Gastric acid secretion |
TREK-1 CRISPR/Cas9 KO Plasmid (m) - sc-421244 from Santa Cruz Biotechnology
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TREK-1 HDR Plasmid (m) - sc-421244-HDR from Santa Cruz Biotechnology
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TREK-1 Double Nickase Plasmid (m) - sc-421244-NIC from Santa Cruz Biotechnology
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TREK-1 Double Nickase Plasmid (m2) - sc-421244-NIC-2 from Santa Cruz Biotechnology
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TREK-1 CRISPR Activation Plasmid (m) - sc-421244-ACT from Santa Cruz Biotechnology
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TREK-1 CRISPR Activation Plasmid (m2) - sc-421244-ACT-2 from Santa Cruz Biotechnology
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TREK-1 Lentiviral Activation Particles (m) - sc-421244-LAC from Santa Cruz Biotechnology
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TREK-1 Lentiviral Activation Particles (m2) - sc-421244-LAC-2 from Santa Cruz Biotechnology
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TREK-1 siRNA (m) - sc-37181 from Santa Cruz Biotechnology
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TREK-1 shRNA Plasmid (m) - sc-37181-SH from Santa Cruz Biotechnology
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TREK-1 shRNA (m) Lentiviral Particles - sc-37181-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU045921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34172 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34172 from Sigma-Aldrich
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KCNK2 siRNA (Mouse) - CRM2185 from Cohesion Biosciences
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shRNA set against Mouse KCNK2 (NM_010607.2) - SHH323451 from Creative biogene
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Mouse KCNK2 siRNA - orb281661 from Biorbyt
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KCNK2 shRNA Plasmid (Mouse) - CHM2185 from Cohesion Biosciences
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