| Gene Symbol |
HIST1H2AB
|
| Entrez Gene |
8335
|
| Alt Symbol |
H2A/m, H2AFM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H2ab
|
| Other Description |
H2A histone family, member M|histone 1, H2ab|histone H2A type 1-B/E|histone H2A/m
|
| Swissprots |
Q76P63 P28001 P04908
|
| Accessions |
AAN59964 CAA24951 CAB06036 EAW55512 AK311785 BAG34728 BC125140 AAI25141 BC166650 AAI66650 NM_003513 NP_003504
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Top Pathways |
Systemic lupus erythematosus, Alcoholism
|
![Western Blot: HIST1H2AB Overexpression Lysate (Adult Normal) [NBP2-07997] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HIST1H2AB.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9895_HIST1H2AB%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07997-img0001.jpg)