| Gene Symbol | FOLH1 |
|---|---|
| Entrez Gene | 2346 |
| Alt Symbol | FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP |
| Species | Human |
| Gene Type | protein-coding |
| Description | folate hydrolase (prostate-specific membrane antigen) 1 |
| Other Description | N-acetylated alpha-linked acidic dipeptidase 1|N-acetylated-alpha-linked acidic dipeptidase I|NAALADase I|cell growth-inhibiting gene 27 protein|folylpoly-gamma-glutamate carboxypeptidase|glutamate carboxylase II|glutamate carboxypeptidase 2|glutamate carboxypeptidase II|membrane glutamate carboxypeptidase|prostate specific membrane antigen variant F|pteroylpoly-gamma-glutamate carboxypeptidase |
| Swissprots | B7Z312 E9PDX8 A9CB79 D3DQS5 A4UU12 Q04609 Q9P1P8 Q9NYE2 Q8TAY3 B7Z343 Q541A4 O43748 Q16305 Q9NP15 |
| Accessions | AAC83972 AAF31167 AAP86290 CAM36419 CAM55906 CAM55926 CCA94569 EAW67858 EAW67861 Q04609 AF027824 AF176574 AAD51121 AF254357 AAF71357 AF254358 AAF71358 AJ007318 AK295368 BAH12048 AK295470 BAH12079 AK300532 BAH13299 AK312366 BAG35284 AY101595 AAM34479 BC025672 AAH25672 BC108719 AAI08720 DQ088979 AAZ66619 DQ891167 ABM82093 DQ894349 ABM85275 EF488811 ABO93402 EF488812 ABO93403 M99487 AAA60209 S76978 AAB33750 XM_011519958 XP_011518260 NM_001014986 NP_001014986 NM_001193471 NP_001180400 NM_001193472 NP_001180401 NM_001193473 NP_001180402 NM_004476 NP_004467 |
| Function | Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:9809977}; Single-pass type II membrane protein {ECO:0000269|PubMed:9809977}. |
| Tissue Specificity | Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer. {ECO:0000269|PubMed:14716746, ECO:0000269|PubMed:16555021, ECO:0000269|PubMed:17150306, ECO:0000269|PubMed:9375657}. |
| Top Pathways | Vitamin digestion and absorption, Alanine, aspartate and glutamate metabolism |