Gene Symbol | MPPE1 |
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Entrez Gene | 65258 |
Alt Symbol | PGAP5 |
Species | Human |
Gene Type | protein-coding |
Description | metallophosphoesterase 1 |
Other Description | metallo phosphoesterase|post-GPI attachment to proteins factor 5 |
Swissprots | D3DUI7 B0YJ41 Q8TE26 Q8TAD6 Q8WZ32 B7WNJ3 D3DUI5 B0YJ40 Q9H958 B5ME53 Q53F39 Q9HAI4 Q9BU58 Q6GMP1 B0YJ39 |
Accessions | AAM00277 AAM00278 ACA06017 ACA06018 ACA06019 EAX01561 EAX01562 EAX01563 EAX01564 EAX01565 EAX01566 EAX01567 EAX01568 EAX01569 EAX01570 EAX01571 EAX01572 Q53F39 AF289560 AAL55744 AF363484 AAM00279 AK021647 BAB13863 AK023052 BAB14378 AK054639 BAG51403 AK223450 BAD97170 AK309948 AL833636 AW663162 AX775853 CAE11626 BC002877 AAH02877 BC073994 AAH73994 BG701552 CR738004 DA581276 DB035278 DQ786245 XM_006722340 XP_006722403 XM_006722341 XP_006722404 XM_006722342 XP_006722405 XM_006722343 XP_006722406 XM_006722345 XP_006722408 XM_006722346 XP_006722409 XM_006722347 XP_006722410 XM_006722348 XP_006722411 XM_011525731 XP_011524033 XM_011525732 XP_011524034 XM_011525733 XP_011524035 XM_011525734 XP_011524036 XR_935068 NM_138608 NM_001242904 NP_001229833 NM_023075 NP_075563 NR_040241 NR_040242 NR_040243 |
Function | Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins. {ECO:0000269|PubMed:19837036}. |
Subcellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:19837036}; Multi-pass membrane protein {ECO:0000269|PubMed:19837036}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:19837036}; Multi- pass membrane protein {ECO:0000269|PubMed:19837036}. Note=Also localizes to endoplasmic reticulum exit site. |
Tissue Specificity | Expressed in brain. {ECO:0000269|PubMed:11978971}. |
MPPE1 (P-20) - sc-85070 from Santa Cruz Biotechnology
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Anti-MPPE1 antibody - ab177092 from Abcam
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Anti-MPPE1 antibody - ab87298 from Abcam
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Anti-MPPE1 antibody - ab196280 from Abcam
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Anti-MPPE1 antibody - C-terminal - ab138420 from Abcam
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Anti-MPPE1 / PGAP5 Antibody - LS-C311403 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa260-289) - LS-C323087 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa261-289, PE) - LS-C263473 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa34-334) - LS-C309236 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa107-156) - LS-C102344 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa261-289) - LS-C158290 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa261-289, AP) - LS-C263467 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa261-289, APC) - LS-C263469 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa261-289, Biotin) - LS-C263470 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa261-289, FITC) - LS-C263471 from LifeSpan Bioscience
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Anti-MPPE1 / PGAP5 Antibody (aa261-289, Azide-free, HRP) - LS-C263472 from LifeSpan Bioscience
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MPPE1 Antibody - NBP1-86089 from Novus Biologicals
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MPPE1 Antibody - NBP1-69305 from Novus Biologicals
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MPPE1 Antibody (3E4) - H00065258-M08 from Novus Biologicals
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MPPE1 Antibody - H00065258-D01P from Novus Biologicals
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Anti-MPPE1 antibody produced in rabbit - HPA012639 from Sigma-Aldrich
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Anti-MPPE1, (N-terminal) antibody produced in rabbit - SAB2103344 from Sigma-Aldrich
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Monoclonal Anti-MPPE1, (C-terminal) antibody produced in mouse - SAB1403356 from Sigma-Aldrich
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Anti-MPPE1 antibody produced in rabbit - SAB1411287 from Sigma-Aldrich
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MPPE1 antibody - N-terminal region (ARP49781_P050) - ARP49781_P050 from Aviva Systems Biology
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