| Gene Symbol | BRE |
|---|---|
| Entrez Gene | 9577 |
| Alt Symbol | BRCC4, BRCC45 |
| Species | Human |
| Gene Type | protein-coding |
| Description | brain and reproductive organ-expressed (TNFRSF1A modulator) |
| Other Description | BRCA1-A complex subunit BRE|BRCA1/BRCA2-containing complex subunit 45|BRCA1/BRCA2-containing complex, subunit 4|brain and reproductive organ-expressed protein |
| Swissprots | A8K4X1 D6W563 Q4ZFX8 Q53SD0 D6W562 Q969X9 Q9NXR7 Q13880 Q96P06 |
| Accessions | AAX88935 AAY24156 CCQ43945 EAX00542 EAX00543 EAX00544 EAX00545 EAX00546 EAX00547 EAX00548 Q9NXR7 AF015767 AAB69387 AF420602 AAL17814 AF420603 AAL17816 AF420604 AAL17817 AF420605 AAL17818 AK000097 BAA90943 AK098345 AK123076 BAC85532 AK291086 BAF83775 AL566299 AY438031 AAR30499 BC001251 AAH01251 BG422104 BG422293 BI559404 BU172408 CR994399 DQ891264 ABM82190 DQ894451 ABM85377 L38616 AAA64231 NM_001261840 NP_001248769 NM_004899 NP_004890 NM_199191 NP_954661 NM_199192 NP_954662 NM_199193 NP_954663 NM_199194 NP_954664 |
| Function | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptoti |
| Subcellular Location | Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). |
| Tissue Specificity | Expressed in all cell lines examined. Highly expressed in placenta. {ECO:0000269|PubMed:11676476}. |