BRE

Gene Symbol	BRE
Entrez Gene	9577
Alt Symbol	BRCC4, BRCC45
Species	Human
Gene Type	protein-coding
Description	brain and reproductive organ-expressed (TNFRSF1A modulator)
Other Description	BRCA1-A complex subunit BRE|BRCA1/BRCA2-containing complex subunit 45|BRCA1/BRCA2-containing complex, subunit 4|brain and reproductive organ-expressed protein
Swissprots	A8K4X1 D6W563 Q4ZFX8 Q53SD0 D6W562 Q969X9 Q9NXR7 Q13880 Q96P06
Accessions	AAX88935 AAY24156 CCQ43945 EAX00542 EAX00543 EAX00544 EAX00545 EAX00546 EAX00547 EAX00548 Q9NXR7 AF015767 AAB69387 AF420602 AAL17814 AF420603 AAL17816 AF420604 AAL17817 AF420605 AAL17818 AK000097 BAA90943 AK098345 AK123076 BAC85532 AK291086 BAF83775 AL566299 AY438031 AAR30499 BC001251 AAH01251 BG422104 BG422293 BI559404 BU172408 CR994399 DQ891264 ABM82190 DQ894451 ABM85377 L38616 AAA64231 NM_001261840 NP_001248769 NM_004899 NP_004890 NM_199191 NP_954661 NM_199192 NP_954662 NM_199193 NP_954663 NM_199194 NP_954664
Function	Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptoti
Subcellular Location	Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity	Expressed in all cell lines examined. Highly expressed in placenta. {ECO:0000269|PubMed:11676476}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BRCC45 full length protein - ab160555 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BRCC45 / BRE Antibody Blocking Peptide - LS-E22743 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BRCC45 / BRE Antibody Blocking Peptide - LS-E30389 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human BRE Protein - H00009577-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BRE Blocking Peptide - NBP1-76830PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

BRE / BRCC45 - H00009577-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

BRE / BRCC45 - H00009577-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BRE / BRCC45 Control Peptide - AP30165CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

BRCC45 Peptide - 4329P from ProSci Category Peptide Species Human

BRE fusion protein - ag2256 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human BRCA1-A complex subunit BRE(BRE) - CSB-YP873684HU CSB-EP873684HU CSB-BP873684HU CSB-MP873684HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BRE Recombinant Protein Antigen - NBP1-88359PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

BRE Peptide, Human - M34GP01532H from Creative Peptides Category Peptide Source Synthetic. Species Human

BRCA1-A complex subunit BRE (BRE), Recombinant Protein - MBS1133579 from MyBioSource Category Protein Prices $1,155.00, $1,155.00, $1,380.00, $1,380.00, $1,840.00, $1,840.00, $2,305.00, $2,305.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

BRCA1-A complex subunit BRE (BRE), Recombinant Protein - MBS1406320 from MyBioSource Category Protein Prices $1,155.00, $1,155.00, $1,380.00, $1,380.00, $1,840.00, $1,840.00, $2,305.00, $2,305.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

BRCA1-A complex subunit BRE (BRE), Recombinant Protein - MBS1312181 from MyBioSource Category Protein Prices $1,155.00, $1,155.00, $1,380.00, $1,380.00, $1,840.00, $1,840.00, $2,305.00, $2,305.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

BRCA1-A complex subunit BRE (BRE), Recombinant Protein - MBS1339869 from MyBioSource Category Protein Prices $1,155.00, $1,155.00, $1,380.00, $1,380.00, $1,840.00, $1,840.00, $2,305.00, $2,305.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

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