EME1

Gene Symbol EME1
Entrez Gene 146956
Alt Symbol MMS4L, SLX2A
Species Human
Gene Type protein-coding
Description essential meiotic structure-specific endonuclease 1
Other Description MMS4 homolog|SLX2 structure-specific endonuclease subunit homolog A|crossover junction endonuclease EME1|essential meiotic endonuclease 1 homolog 1|essential meiotic endonuclease 1 homolog 2|hMMS4|homolog of yeast EME1 endonuclease
Swissprots Q96N62 Q96AY2
Accessions EAW94617 EAW94618 EAW94619 EAW94620 EAW94621 Q96AY2 AK021607 AK055926 BAB71047 AK308275 BC016470 AAH16470 DA006645 DB245967 DQ578819 JF432239 ADZ15456 XM_005257081 XP_005257138 XM_011524392 XP_011522694 XM_011524393 XP_011522695 XM_011524394 XP_011522696 XM_011524395 XP_011522697 XM_011524396 XP_011522698 XR_934390 XR_934392 XR_934393 NM_001166131 NP_001159603 NM_152463 NP_689676
Function Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:14617801}. Note=Recruited to regions of DNA damage in S-phase cells.
Top Pathways Homologous recombination, Fanconi anemia pathway

Eme1 (E-6) - sc-390971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Eme1 (E-6): sc-390971. Western blot analysis of Eme1 expression in HeLa (A), K-562 (B), Jurkat (C) and SW480 (D) nuclear extracts.

Eme1 (MTA31 7h2/1) - sc-53275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Eme1 (MTA31 7h2/1): sc-53275. Western blot analysis of Eme1 expression in HeLa whole cell lysate.

Eme1 (C-15) - sc-164263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Eme1 (H-300) - sc-135140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Eme1 (H-300): sc-135140. Western blot analysis of Eme1 expression in HeLa (A), Jurkat (B), K-562 (C) and SW480 (D) nuclear extracts.

Eme1 (N-25) - sc-130135 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Eme1 (N-25): sc-130135. Western blot analysis of Eme1 expression in 293 showing nontransfected (A) and transfected (B) whole cell lysates.

Anti-EME1 antibody - ab88878 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-EME1 antibody (ab88878) at 1 µg/ml + HeLa cell lysate at 50 µg

Anti-EME1 antibody - ab87170 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-EME1 antibody (ab87170) at 1 µg/ml + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-EME1 antibody - ab89969 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EME1 antibody (ab89969) at 1 µg/ml + HT1080 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-EME1 antibody [mta317h2/1] - ab14392 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone mta317h2/1

Anti-EME1 antibody - N-terminal - ab70921 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EME1 antibody - N-terminal (ab70921) at 1/50 dilutionLane 1 : Nontransfected 293 cell lysatesLane 2 : 293 cell lysates transiently transfected with the EME1 geneLysates/proteins at 2 µg per lane.

Anti-EME1 antibody - N-terminal - ab187359 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-EME1 antibody - N-terminal (ab187359) at 1/1000 dilution + HeLa cell lysate

Anti-EME1 Antibody (clone 7h2/1) - LS-C82283 from LifeSpan Bioscience

Prices $380.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 7h2/1

Anti-EME1 Antibody - LS-C307393 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-EME1 Antibody (C-Terminus) - LS-C111455 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EME1 antibody LS-C111455 Western blot of HT1080 cell lysate.

Anti-EME1 Antibody (N-Terminus) - LS-C102503 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EME1 antibody LS-C102503 Western blot of 293T cell lysate.

EME1 Antibody - NBP1-56286 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: EME1 Antibody [NBP1-56286] - Titration: 0.2-1 ug/ml, Positive Control: 293T cell lysate.

EME1 Antibody - NBP1-55350 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EME1 Antibody [NBP1-55350] - Titration: 0.2-1 ug/ml, Positive Control: HT1080 cell lysate.

EME1 Antibody - H00146956-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: EME1 Antibody [H00146956-B01] - analysis of EME1 expression in transfected 293T cell line by EME1 MaxPab polyclonal antibody (B01). Lane 1: EME1 transfected lysate (64.80 KDa). Lane 2: Non-transfected lysate.

EME1 Antibody - NBP1-32024 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

EME1 Antibody - NBP2-16325 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EME1 Antibody [NBP2-16325] - Sample (30 ug of whole cell lysate) A: HeLa 7. 5% SDS PAGE gel, diluted at 1:1000.

EME1 Antibody - H00146956-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: EME1 Antibody [H00146956-B01P] - Analysis of EME1 expression in Jurkat.

EME1 Polyclonal Antibody - bs-7861R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EME1 (N-term) antibody produced in rabbit - SAB1300345 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-EME1 (N-term) Antibody: <B>Cat. No. SAB1300345</B>: EME1 in HEK 293 cell line lysates either non-transfected (Lane 1) or transiently transfected (Lane 2) with Anti-EME1 (N-term) Antibody at 4.0 μg/mL.

Anti-EME1 antibody produced in rabbit - SAB2103736 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-EME1, antibody produced in rabbit: <B>Cat. No. SAB2103736</B>: Immunoblotting analysis of EME1 in HT1080 cell lysate with EME1 anitbody at 1 μg/mL.

Anti-EME1 (center) antibody produced in rabbit - SAB1300758 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-EME1 (Center) Antibody: <B>Cat. No. SAB1300758</B>: EME1 in HEK 293 cell line lysates either non-transfected (Lane 1) or transiently transfected (Lane 2) with Anti-EME1 (Center) Antibody at 4.0 μg/mL.
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