KCNIP3

Gene Symbol KCNIP3
Entrez Gene 30818
Alt Symbol CSEN, DREAM, KCHIP3
Species Human
Gene Type protein-coding
Description Kv channel interacting protein 3, calsenilin
Other Description A-type potassium channel modulatory protein 3|DRE-antagonist modulator|calsenilin|calsenilin, presenilin-binding protein, EF hand transcription factor|kv channel-interacting protein 3|potassium channel interacting protein 3
Swissprots Q9UJ84 Q3YAC4 H7BY46 Q96T40 Q9Y2W7 Q3YAC3 Q53TJ5 Q9UJ85
Accessions AAY14752 EAX10723 EAX10724 EAX10725 EAX10726 EAX10727 Q9Y2W7 AB209076 BAD92313 AF120102 AAD20350 AF199599 AAF33684 AF367022 AAK53711 AJ131730 CAB56835 AK095539 AK315437 BAG37825 BC012850 AAH12850 BI755669 BT020075 AAV38878 BX491997 DQ148485 AAZ77802 DQ148486 AAZ77803 DQ892078 ABM83004 DQ895271 ABM86197 DQ895316 ABM86242 XR_922912 NM_001034914 NP_001030086 NM_013434 NP_038462
Function May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. {ECO:0000269|PubMed:11259376, ECO:0000269|PubMed:11988022, ECO:0000269|PubMed:9771752}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18957440}. Cell membrane {ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:18957440}; Lipid-anchor {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:18957440}. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000250, ECO:0000269|PubMed:15485870}.
Tissue Specificity Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. {ECO:0000269|PubMed:14720210}.

DREAM (A-9) - sc-166916 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DREAM (A-9): sc-166916. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

DREAM (FL-214) - sc-9142 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DREAM (FL-214): sc-9142. Western blot analysis of DREAM expression in non-transfected: sc-110760 (A) and human DREAM transfected: sc-111016 (B) 293 whole cell lysates.

DREAM (K-17) - sc-9309 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DREAM (K-17): sc-9309. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing nuclear staining of Purkinje cell, cells in granular layer and cells in molecular layer.

Anti-CSEN (phospho S63) antibody - ab62439 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of CSEN in HeLa cells, using ab62439 (1/500); in the presence or absence of phosphopeptide.

Anti-CSEN antibody - ab3474 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunolocalization of CSEN in Rabbit granule cells using ab3474.

Anti-CSEN antibody - ab61770 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human brain tissue using ab61770 at a dilution of 1/50. left: untreated sample. Right: sample treated with immunising peptide.

Anti-CSEN antibody - ab133212 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cortex neurons labelling CSEN with ab133212 at 10 µg/ml, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-CSEN antibody - ab41717 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CSEN antibody - ab59936 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab59936 (1/50-1/100) staining human CSEN in human cancer tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. HC = hepatocarcinoma.

Anti-CSEN antibody - ab57203 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57203 CSEN antibody at 1ug/ml.

Anti-CSEN antibody [S66-38] - ab99043 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S66-38
Immunohistochemical detection of CSEN in frozen sections of Mouse brain extract using ab99043.

Anti-KCNIP3 / Dream / Calsenilin Antibody (N-Terminus, AP) - LS-C244088 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody (N-Terminus, APC) - LS-C244087 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody (N-Terminus, Biotin) - LS-C244090 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody (N-Terminus, PE) - LS-C244095 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody - LS-C310008 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody - LS-C310009 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody (N-Terminus, Azide-free, HRP) - LS-C247522 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody - LS-C307831 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody (clone 2B3-A1) - LS-C307832 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B3-A1

Anti-KCNIP3 / Dream / Calsenilin Antibody (N-Terminus, FITC) - LS-C244089 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody (aa29-78) IHC-plus™ - LS-B7002 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNIP3 / CSEN antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7002 concentration 10 ug/ml.

Anti-KCNIP3 / Dream / Calsenilin Antibody (aa1-16) - LS-C313367 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNIP3 / Dream / Calsenilin Antibody (aa26-35) IHC-plus™ - LS-B249 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNIP3 / CSEN antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B249 concentration 5 ug/ml.

Anti-KCNIP3 / Dream / Calsenilin Antibody (N-Terminus) - LS-C330401 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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