| Gene Symbol |
KCNIP3
|
| Entrez Gene |
30818
|
| Alt Symbol |
CSEN, DREAM, KCHIP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Kv channel interacting protein 3, calsenilin
|
| Other Description |
A-type potassium channel modulatory protein 3|DRE-antagonist modulator|calsenilin|calsenilin, presenilin-binding protein, EF hand transcription factor|kv channel-interacting protein 3|potassium channel interacting protein 3
|
| Swissprots |
Q9UJ84 Q3YAC4 H7BY46 Q96T40 Q9Y2W7 Q3YAC3 Q53TJ5 Q9UJ85
|
| Accessions |
AAY14752 EAX10723 EAX10724 EAX10725 EAX10726 EAX10727 Q9Y2W7 AB209076 BAD92313 AF120102 AAD20350 AF199599 AAF33684 AF367022 AAK53711 AJ131730 CAB56835 AK095539 AK315437 BAG37825 BC012850 AAH12850 BI755669 BT020075 AAV38878 BX491997 DQ148485 AAZ77802 DQ148486 AAZ77803 DQ892078 ABM83004 DQ895271 ABM86197 DQ895316 ABM86242 XR_922912 NM_001034914 NP_001030086 NM_013434 NP_038462
|
| Function |
May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. {ECO:0000269|PubMed:11259376, ECO:0000269|PubMed:11988022, ECO:0000269|PubMed:9771752}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18957440}. Cell membrane {ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:18957440}; Lipid-anchor {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:18957440}. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000250, ECO:0000269|PubMed:15485870}.
|
| Tissue Specificity |
Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. {ECO:0000269|PubMed:14720210}.
|