Gene Symbol | BRD3 |
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Entrez Gene | 8019 |
Alt Symbol | ORFX, RING3L |
Species | Human |
Gene Type | protein-coding |
Description | bromodomain containing 3 |
Other Description | RING3-like protein|bromodomain-containing 3|bromodomain-containing protein 3 |
Swissprots | Q5T1R7 Q8N5M3 Q92645 Q15059 B1APD9 Q4G5Y3 |
Accessions | EAW88113 EAW88114 EAW88115 Q15059 AA766480 AF052138 AK026880 AK123322 AK299519 BAG61471 AW409970 AY513270 AAS82952 BC010699 BC030095 BC032124 AAH32124 BI545861 D26362 BAA05393 DW413353 XM_005272214 XP_005272271 XM_006717291 XP_006717354 XM_011519052 XP_011517354 NM_007371 NP_031397 |
Function | Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene. {ECO:0000250, ECO:0000269|PubMed:18406326}. |
Subcellular Location | Nucleus {ECO:0000305}. Note=Detected on chromatin. {ECO:0000250}. |
Tissue Specificity | Ubiquitous. |
BRD3 CRISPR/Cas9 KO Plasmid (h) - sc-401493 from Santa Cruz Biotechnology
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BRD3 HDR Plasmid (h) - sc-401493-HDR from Santa Cruz Biotechnology
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BRD3 Double Nickase Plasmid (h) - sc-401493-NIC from Santa Cruz Biotechnology
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BRD3 Double Nickase Plasmid (h2) - sc-401493-NIC-2 from Santa Cruz Biotechnology
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BRD3 CRISPR Activation Plasmid (h) - sc-401493-ACT from Santa Cruz Biotechnology
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BRD3 CRISPR Activation Plasmid (h2) - sc-401493-ACT-2 from Santa Cruz Biotechnology
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BRD3 Lentiviral Activation Particles (h) - sc-401493-LAC from Santa Cruz Biotechnology
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BRD3 Lentiviral Activation Particles (h2) - sc-401493-LAC-2 from Santa Cruz Biotechnology
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BRD3 siRNA (h) - sc-60284 from Santa Cruz Biotechnology
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BRD3 shRNA Plasmid (h) - sc-60284-SH from Santa Cruz Biotechnology
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BRD3 shRNA (h) Lentiviral Particles - sc-60284-V from Santa Cruz Biotechnology
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BRD3 RNAi - H00008019-R01 from Novus Biologicals
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MISSION® esiRNA - EHU151451 from Sigma-Aldrich
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MISSION® siRNA - SIHK0189 from Sigma-Aldrich
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MISSION® siRNA - SIHK0190 from Sigma-Aldrich
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MISSION® siRNA - SIHK0191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4049 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4049 from Sigma-Aldrich
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BRD3 siRNA (Human) - CRH5340 from Cohesion Biosciences
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BRD3 - MBS8225334 from MyBioSource
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shRNA set against Human BRD3 (NM_007371.3) - SHH247606 from Creative biogene
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BRD3 shRNA Plasmid (Human) - CHH5340 from Cohesion Biosciences
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BRD3 miRNA 3'UTR clone - MiUTR4H-TG00837 from Creative biogene
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