KLRK1

Gene Symbol	KLRK1
Entrez Gene	22914
Alt Symbol	CD314, D12S2489E, KLR, NKG2-D, NKG2D
Species	Human
Gene Type	protein-coding
Description	killer cell lectin-like receptor subfamily K, member 1
Other Description	NK cell receptor D|NKG2-D type II integral membrane protein|NKG2-D-activating NK receptor
Swissprots	A8K7P4 A8K7K5 Q9NR41 P26718
Accessions	ABF50044 CAA04925 EAW96178 EAW96180 EAW96182 P26718 AF260135 AAF86973 AF260136 AAF86974 AK226161 AK292059 BAF84748 BC039836 AAH39836 CB241686 DA933271 DA960048 NM_007360 NP_031386
Function	Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. {ECO:0000269|PubMed:10426994, ECO:0000269|
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}; Single- pass type II membrane protein {ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11015446, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST on the cell surface.
Tissue Specificity	Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs). {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:15294961, ECO:0000269|PubMed:16444266}.
Top Pathways	Natural killer cell mediated cytotoxicity, Malaria

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NKG2D protein fragment - ab137140 from Abcam Category Protein Source E. coli Species Human

NKG2D peptide (136-147) - ab45787 from Abcam Category Peptide Species Human

KLRK1 / CD314 / NKG2D Antibody Blocking Peptide - LS-E25911 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KLRK1 / CD314 / NKG2D Antibody Blocking Peptide - LS-E23082 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KLRK1 / CD314 / NKG2D Antibody Blocking Peptide - LS-E23081 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NKG2D/CD314 Recombinant Protein - H00022914-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human NKG2D/CD314 Protein - NBP2-23173 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

NKG2D-Antibody-N-term-Blocking-peptide - BP13295a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NKG2D blocking peptide - GTX89520-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Recombinant Human NKG2D Fc Chimera, CF - 1299-NK-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse NKG2D Fc Chimera, CF - 139-NK-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human KLRK1 protein - orb168706 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human CD314 protein - orb138406 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source CHO Stable Cells Species Human

Human CD314 protein (His Tag) - orb138404 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

KLRK1 protein (His tag) - 80R-2596 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

NKG2D Peptide - AC21-0741-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD314 / KLRK1 (73-216, His-tag) - AR50642PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CD314 / KLRK1 (73-216, His-tag) - AR50642PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CD314 / KLRK1 - H00022914-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

KLRK1, 73-216 aa, Human, His tag, E.coli - 01-P1818 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

KLRK1 Peptide - 45-079P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

KLRK1 fusion protein - ag8054 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

KLRK1 fusion protein - ag5929 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

KLRK1 Human - PRPS-1297 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human KLRC4-KLRK1 - KLRC4-KLRK1-1538H from Creative Biomart Category Protein Source Mammalian Cells Species Human

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