MUC1
| Gene Symbol | MUC1 |
|---|---|
| Entrez Gene | 4582 |
| Alt Symbol | ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM |
| Species | Human |
| Gene Type | protein-coding |
| Description | mucin 1, cell surface associated |
| Other Description | DF3 antigen|H23 antigen|Medullary cystic kidney disease, autosomal dominant|breast carcinoma-associated antigen DF3|cancer antigen 15-3|carcinoma-associated mucin|episialin|krebs von den Lungen-6|mucin 1, transmembrane|mucin-1|peanut-reactive urinary mucin|polymorphic epithelial mucin|tumor associated epithelial mucin|tumor-associated epithelial membrane antigen |
| Swissprots | E7EUG9 Q9UQL1 Q7Z552 Q7Z547 Q16437 Q0VAP5 A6ZIE0 P13931 Q9UE75 Q9BXA4 Q14876 P15942 Q16615 Q14128 A5YRV1 Q7Z548 Q9Y4J2 Q6S4Y3 E7ESE5 P15941 Q0VAP6 Q16442 Q9UE76 B1AVR0 B1AVQ8 B6ECA1 A6ZID9 P17626 Q7Z550 |
| Accessions | AAA57348 AAB53150 AAB59612 AAN87067 AAR18816 CCA94570 EAW53112 EAW53113 EAW53116 EAW53117 EAW53118 EAW53119 P15941 AA425062 AF125525 AAD27842 AF348143 AAK30142 AK301575 BAG63068 AY327582 AAP97013 AY327583 AAP97014 AY327584 AAP97015 AY327585 AAP97016 AY327586 AAP97017 AY327587 AAP97018 AY327588 AAP97019 AY327589 AAP97020 AY327590 AAP97021 AY327591 AAP97022 AY327592 AAP97023 AY327595 AAP97024 AY327596 AAP97025 AY327597 AAP97026 AY327598 AAP97027 AY327599 AAP97028 AY327600 AAP97029 AY466157 AAR28764 BC120974 AAI20975 BC120975 AAI20976 BM969296 BM971650 EF583642 ABQ59617 EF583643 ABQ59618 EF583644 ABQ59619 EF583645 ABQ59620 EF583646 ABQ59621 EF583647 ABQ59622 EF583648 ABQ59623 EF583649 ABQ59624 EF583650 ABQ59625 EF583651 ABQ59626 EF583652 ABQ59627 EF583653 ABQ59628 EF583654 ABQ59629 EF583655 ABQ59630 EF583656 ABQ59631 EF670706 ABS01293 EF670707 ABS01294 EF670708 ABS01295 EF670709 ABS01296 EF670710 ABS01297 EF670711 ABS01298 EF670712 ABS01299 EF670713 ABS01300 EF670714 ABS01301 EF670715 ABS01302 EF670716 ABS01303 EF670717 ABS01304 EF670718 ABS01305 EF670719 ABS01306 EF670720 ABS01307 EF670721 ABS01308 EF670722 ABS01309 EF670723 ABS01310 FJ226028 ACI25160 FJ226029 ACI25161 FJ226030 ACI25162 FJ226031 ACI25163 FJ226032 ACI25164 FJ226033 ACI25165 FJ226034 ACI25166 FJ226035 ACI25167 FJ226036 ACI25168 FJ226037 ACI25169 FJ226038 ACI25170 FJ226039 ACI25171 FJ226040 ACI25172 FJ226041 ACI25173 FJ226042 ACI25174 FJ226043 ACI25175 FJ226044 ACI25176 FJ226045 ACI25177 FJ226046 ACI25178 FJ226047 ACI25179 FJ226049 ACI25180 FJ226050 ACI25181 FJ226051 ACI25182 FJ226052 ACI25183 FJ226053 ACI25184 FJ226054 ACI25185 FJ226055 ACI25186 J05581 AAA59876 J05582 AAA60019 M26316 AAA36336 M31823 AAA35757 M32738 AAA35804 M32739 AAA35806 M34088 AAA35805 M34089 AAA35807 S81736 AAD14369 S81781 AAD14376 U60259 AAD10856 U60260 AAD10857 U60261 AAD10858 X52228 CAA36477 X52229 CAA36478 X80761 CAA56734 Z17324 CAA78972 Z17325 CAA78973 NM_001018016 NP_001018016 NM_001018017 NP_001018017 NM_001044390 NP_001037855 NM_001044391 NP_001037856 NM_001044392 NP_001037857 NM_001044393 NP_001037858 NM_001204285 NP_001191214 NM_001204286 NP_001191215 NM_001204287 NP_001191216 NM_001204288 NP_001191217 NM_001204289 NP_001191218 NM_001204290 NP_001191219 NM_001204291 NP_001191220 NM_001204292 NP_001191221 NM_001204293 NP_001191222 NM_001204294 NP_001191223 NM_001204295 NP_001191224 NM_001204296 NP_001191225 NM_001204297 NP_001191226 NM_002456 NP_002447 NM_001018021 NM_182741 |
| Function | The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. |
| Subcellular Location | Mucin-1 subunit beta: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus. |
| Tissue Specificity | Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only. {ECO:0000269|PubMed:15513966, ECO:0000269|PubMed:9212228}. |
Human CA 15-3 ELISA Kit (Sandwich ELISA) - LS-F10002 from LifeSpan Bioscience
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Human EMA / MUC1 ELISA Kit (Sandwich ELISA) - LS-F5255 from LifeSpan Bioscience
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Mouse EMA / MUC1 ELISA Kit (Sandwich ELISA) - LS-F6240 from LifeSpan Bioscience
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Rat EMA / MUC1 ELISA Kit (Sandwich ELISA) - LS-F6241 from LifeSpan Bioscience
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Human Carbohydrate Antigen 15-3 / Mucin-1 ELISA Kit - RAB0375 from Sigma-Aldrich
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CA15-3 ELISA Kit - SE120153 from Sigma-Aldrich
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CA 15-3 ELISA kit - 55R-IB19123 from Fitzgerald
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Anti-Endomysial antibody (EMA) (IgA), Human, ELISA Kit - CSB-E08828h from ARP American Research Products
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Anti-Endomysial antibody (EMA) (IgA), Human, ELISA Kit - E01A1847 from ARP American Research Products
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Anti-Endomysial antibody (EMA) (IgG), Human, ELISA Kit - E01A1848 from ARP American Research Products
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Anti-Endomysial (EMA) antibody (IgG), Human, ELISA kit - CSB-EQ027572HU from ARP American Research Products
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Electron Transfer Flavoprotein Alpha Polypeptide (ETFa), Human, ELISA Kit - SEE527Hu from ARP American Research Products
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Epithelial Membrane Antigen, EMA, Human, ELISA Kit - E-EL-H1878 from ARP American Research Products
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Malonyl-CoA decarboxylase, mitochondrial (MLYCD), Human, ELISA Kit - CSB-EL014646HU from ARP American Research Products
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Mucin 1, MUC1, Human, ELISA Kit - E-EL-H0616 from ARP American Research Products
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Mucin 1 (MUC1), Human, ELISA Kit - SEA413Hu from ARP American Research Products
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Mucin-1, MUC1, Human, ELISA Kit - E0413h from ARP American Research Products
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Epithelial Membrane Antigen, EMA, Rabbit, ELISA Kit - E-EL-RB0195 from ARP American Research Products
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Mucin 1, MUC1, Rabbit, ELISA Kit - E-EL-RB0577 from ARP American Research Products
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Epithelial Membrane Antigen, EMA, Chicken, ELISA Kit - E-EL-Ch0175 from ARP American Research Products
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Mucin 1, MUC1, Chicken, ELISA Kit - E-EL-Ch0477 from ARP American Research Products
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Epithelial Membrane Antigen, EMA, Porcine, ELISA Kit - E-EL-P0695 from ARP American Research Products
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MUC1 (Mucin 1), Pig, ELISA Kit - E-EL-P0676 from ARP American Research Products
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Epithelial Membrane Antigen, EMA, Sheep, ELISA Kit - E-EL-S0917 from ARP American Research Products
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Mucin 1, MUC1, Sheep, ELISA Kit - E-EL-S0068 from ARP American Research Products
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