Sun2

Gene Symbol Sun2
Entrez Gene 223697
Alt Symbol B230369L08Rik, C030011B15, Unc84b
Species Mouse
Gene Type protein-coding
Description Sad1 and UNC84 domain containing 2
Other Description SUN domain-containing protein 2|protein unc-84 homolog B|sad1/unc-84 protein-like 2
Swissprots Q8BJS4 Q6B4H2 Q3U160 Q3TBU0
Accessions EDL04635 EDL04636 EDL04637 Q8BJS4 AK046318 AK047688 AK080116 BAC37829 AK085196 AK128958 BAC87662 AK156246 BAE33640 AK171058 BAE42217 AK172398 AK172996 BAD32274 AY682987 AAT90499 BC023965 BC027394 BC098208 AAH98208 BQ879674 DV660654 XM_006520811 XP_006520874 NM_001205345 NP_001192274 NM_001205346 NP_001192275 NM_194342 NP_919323
Function Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, Syne2 and Sun2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5. {ECO:0000269|Pu
Subcellular Location Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Highly expressed in heart, placenta and muscle. {ECO:0000269|PubMed:12393179}.

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