| Gene Symbol | ARNT |
|---|---|
| Entrez Gene | 405 |
| Alt Symbol | HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aryl hydrocarbon receptor nuclear translocator |
| Other Description | class E basic helix-loop-helix protein 2|dioxin receptor, nuclear translocator|hypoxia-inducible factor 1, beta subunit |
| Swissprots | B2R9H1 P27540 Q5QP39 F8WAP6 Q8NDC7 Q59ED4 C4AMA1 |
| Accessions | AAQ96598 AEI91786 AEI91787 CAB65056 CAB69528 CAC21446 EAW53510 EAW53511 EAW53512 EAW53513 EAW53514 P27540 AB209877 BAD93114 AF001307 AAC03365 AK223459 BAD97179 AK290177 BAF82866 AK291705 BAF84394 AK293027 BAF85716 AK304772 BAG65527 AK313780 BAG36518 AK315812 BAF98703 AL834279 CAD38953 BC028362 BC041121 BC060838 AAH60838 BU730937 HQ448538 ADQ33017 M69238 AAA51777 XM_005245151 XP_005245208 XM_005245153 XP_005245210 XM_005245154 XP_005245211 XM_005245157 XP_005245214 XM_011509542 XP_011507844 XM_011509543 XP_011507845 XM_011509544 XP_011507846 XM_011509545 XP_011507847 XM_011509546 XP_011507848 XM_011509547 XP_011507849 NM_001197325 NP_001184254 NM_001286035 NP_001272964 NM_001286036 NP_001272965 NM_001668 NP_001659 NM_178427 NP_848514 NM_178426 |
| Function | Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. |
| Subcellular Location | Nucleus. |
| Top Pathways | Renal cell carcinoma, Chemical carcinogenesis |