| Gene Symbol |
SMARCD1
|
| Entrez Gene |
6602
|
| Alt Symbol |
BAF60A, CRACD1, Rsc6p
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
|
| Other Description |
60 kDa BRG-1/Brm-associated factor subunit A|BRG1-associated factor 60A|SWI/SNF complex 60 kDa subunit A|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1|Swp73-like protein|chromatin remodeling complex BAF60A subunit|mammalian chromatin remodeling complex BRG1-associated factor 60A
|
| Swissprots |
Q9Y635 Q96GM5 Q92924 A6NN27
|
| Accessions |
EAW58120 EAW58121 EAW58122 EAW58123 EAW58124 EAW58125 EAW58126 EAW58127 Q96GM5 AA610093 AF109733 AAD23390 AK130517 AK292700 BAF85389 AK293932 BAG57311 BC000063 BC009368 AAH09368 BE905082 CN272379 DA825057 DB010252 EU447009 ABZ92538 N75126 U66617 AAC50695 XM_005269107 XP_005269164 XM_011538695 XP_011536997 XR_944683 XR_944684 NM_003076 NP_003067 NM_139071 NP_620710
|
| Function |
Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essent
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:8804307, ECO:0000305}.
|
| Tissue Specificity |
Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta. {ECO:0000269|PubMed:8804307}.
|
![Western Blot: SMARCD1 Overexpression Lysate (Adult Normal) [NBL1-16234] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMARCD1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3605_SMARCD1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16234-img0002.jpg)