Gene Symbol | SMARCD1 |
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Entrez Gene | 6602 |
Alt Symbol | BAF60A, CRACD1, Rsc6p |
Species | Human |
Gene Type | protein-coding |
Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 |
Other Description | 60 kDa BRG-1/Brm-associated factor subunit A|BRG1-associated factor 60A|SWI/SNF complex 60 kDa subunit A|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1|Swp73-like protein|chromatin remodeling complex BAF60A subunit|mammalian chromatin remodeling complex BRG1-associated factor 60A |
Swissprots | Q9Y635 Q96GM5 Q92924 A6NN27 |
Accessions | EAW58120 EAW58121 EAW58122 EAW58123 EAW58124 EAW58125 EAW58126 EAW58127 Q96GM5 AA610093 AF109733 AAD23390 AK130517 AK292700 BAF85389 AK293932 BAG57311 BC000063 BC009368 AAH09368 BE905082 CN272379 DA825057 DB010252 EU447009 ABZ92538 N75126 U66617 AAC50695 XM_005269107 XP_005269164 XM_011538695 XP_011536997 XR_944683 XR_944684 NM_003076 NP_003067 NM_139071 NP_620710 |
Function | Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essent |
Subcellular Location | Nucleus {ECO:0000269|PubMed:8804307, ECO:0000305}. |
Tissue Specificity | Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta. {ECO:0000269|PubMed:8804307}. |
BAF60a CRISPR/Cas9 KO Plasmid (h) - sc-402641 from Santa Cruz Biotechnology
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BAF60a HDR Plasmid (h) - sc-402641-HDR from Santa Cruz Biotechnology
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BAF60a Double Nickase Plasmid (h) - sc-402641-NIC from Santa Cruz Biotechnology
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BAF60a Double Nickase Plasmid (h2) - sc-402641-NIC-2 from Santa Cruz Biotechnology
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BAF60a CRISPR Activation Plasmid (h) - sc-402641-ACT from Santa Cruz Biotechnology
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BAF60a CRISPR Activation Plasmid (h2) - sc-402641-ACT-2 from Santa Cruz Biotechnology
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BAF60a Lentiviral Activation Particles (h) - sc-402641-LAC from Santa Cruz Biotechnology
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BAF60a Lentiviral Activation Particles (h2) - sc-402641-LAC-2 from Santa Cruz Biotechnology
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BAF60a siRNA (h) - sc-72597 from Santa Cruz Biotechnology
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BAF60a shRNA Plasmid (h) - sc-72597-SH from Santa Cruz Biotechnology
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BAF60a shRNA (h) Lentiviral Particles - sc-72597-V from Santa Cruz Biotechnology
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SMARCD1 RNAi - H00006602-R02 from Novus Biologicals
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MISSION® esiRNA - EHU068881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19769 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19769 from Sigma-Aldrich
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SMARCD1 siRNA (Human) - CRH4485 from Cohesion Biosciences
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SMARCD1 RNAi - H00006602-R01 from Novus Biologicals
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SMARCD1 - MBS8203906 from MyBioSource
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shRNA set against Human SMARCD1 (NM_003076.4) - SHH413180 from Creative biogene
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shRNA set against Human SMARCD1(NM_139071.2) - SHL015838 from Creative biogene
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shRNA set against Human SMARCD1(NM_003076.4) - SHL016014 from Creative biogene
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Human SMARCD1 siRNA - orb264987 from Biorbyt
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SMARCD1 shRNA Plasmid (Human) - CHH4485 from Cohesion Biosciences
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SMARCD1 miRNA 3'UTR clone - MiUTR1H-09647 from Creative biogene
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SMARCD1 miRNA 3'UTR clone - MiUTR1H-09648 from Creative biogene
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