SMAD1
| Gene Symbol | SMAD1 |
|---|---|
| Entrez Gene | 4086 |
| Alt Symbol | BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SMAD family member 1 |
| Other Description | MAD homolog 1|MAD, mothers against decapentaplegic homolog 1|Mad-related protein 1|SMAD, mothers against DPP homolog 1|TGF-beta signaling protein 1|mothers against DPP homolog 1|mothers against decapentaplegic homolog 1|transforming growth factor-beta signaling protein 1|transforming growth factor-beta-signaling protein 1 |
| Swissprots | A8KAJ0 Q9UFT8 Q15797 Q16636 D3DNZ9 |
| Accessions | CAB55898 CBY84968 EAX05037 EAX05038 EAX05039 EAX05040 Q15797 AK096624 AK293055 BAF85744 BC001878 AAH01878 BE644607 BI772689 BI792941 BQ962660 BT007386 AAP36050 BU163870 CB956339 DQ892510 ABM83436 DQ895724 ABM86650 U54826 AAC50493 U57456 AAC50621 U59423 AAB06852 U59912 AAC50790 XM_005262991 XP_005263048 XM_005262992 XP_005263049 XM_005262993 XP_005263050 XM_006714217 XP_006714280 XM_011531961 XP_011530263 XM_011531962 XP_011530264 XM_011531963 XP_011530265 XM_011531964 XP_011530266 NM_001003688 NP_001003688 NM_005900 NP_005891 |
| Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. {ECO:0000269|PubMed:12097147}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane. |
| Tissue Specificity | Ubiquitous. Highest expression seen in the heart and skeletal muscle. |
| Top Pathways | TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer |
Human Smad1 full length protein - ab84653 from Abcam
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Human Smad1 full length protein - ab152029 from Abcam
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Human Smad1 peptide - ab66722 from Abcam
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SMAD1 Protein Lysate (APL10837) - APL10837 from Aviva Systems Biology
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SMAD1 Protein Lysate (APL10839) - APL10839 from Aviva Systems Biology
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Human SMAD1 protein - orb49658 from Biorbyt
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SMAD1 - H00004086-P01-10 from Acris Antibodies
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SMAD1 - H00004086-P01-25 from Acris Antibodies
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SMAD1 - H00004086-Q01-10 from Acris Antibodies
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SMAD1 - H00004086-Q01-25 from Acris Antibodies
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SMAD1 - H00004086-Q03-10 from Acris Antibodies
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SMAD1 - H00004086-Q03-25 from Acris Antibodies
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Smad1, MAD homolog 1, Human, Recombinant - 19-CE81 from ARP American Research Products
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SMAD1 fusion protein - Ag0701 from Proteintech Group
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Recombinant Human SMAD1 Protein - BP001719-CE81 from Syd Labs
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Recombinant Human SMAD Family Member 1, GST-tagged - SMAD1-1489H from Creative Biomart
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Recombinant Human SMAD1 - SMAD1-30445TH from Creative Biomart
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Recombinant Human SMAD1, GST-tagged - SMAD1-2799H from Creative Biomart
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Recombinant Human SMAD1, His-tagged - SMAD1-11H from Creative Biomart
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Recombinant Human SMAD1, MYC/DDK-tagged - SMAD1-12H from Creative Biomart
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Recombinant Human SMAD Family Member 1, GST-tagged - SMAD1-1092H from Creative Biomart
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Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) - RPA647Hu01 from Uscn Life Science Inc.
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Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) - RPA647Mu01 from Uscn Life Science Inc.
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Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) - RPA647Ra01 from Uscn Life Science Inc.
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SMAD1 (pS187) Blocking Peptide - CBP1704 from Cohesion Biosciences
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