SMAD1

Gene Symbol	SMAD1
Entrez Gene	4086
Alt Symbol	BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
Species	Human
Gene Type	protein-coding
Description	SMAD family member 1
Other Description	MAD homolog 1|MAD, mothers against decapentaplegic homolog 1|Mad-related protein 1|SMAD, mothers against DPP homolog 1|TGF-beta signaling protein 1|mothers against DPP homolog 1|mothers against decapentaplegic homolog 1|transforming growth factor-beta signaling protein 1|transforming growth factor-beta-signaling protein 1
Swissprots	A8KAJ0 Q9UFT8 Q15797 Q16636 D3DNZ9
Accessions	CAB55898 CBY84968 EAX05037 EAX05038 EAX05039 EAX05040 Q15797 AK096624 AK293055 BAF85744 BC001878 AAH01878 BE644607 BI772689 BI792941 BQ962660 BT007386 AAP36050 BU163870 CB956339 DQ892510 ABM83436 DQ895724 ABM86650 U54826 AAC50493 U57456 AAC50621 U59423 AAB06852 U59912 AAC50790 XM_005262991 XP_005263048 XM_005262992 XP_005263049 XM_005262993 XP_005263050 XM_006714217 XP_006714280 XM_011531961 XP_011530263 XM_011531962 XP_011530264 XM_011531963 XP_011530265 XM_011531964 XP_011530266 NM_001003688 NP_001003688 NM_005900 NP_005891
Function	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. {ECO:0000269|PubMed:12097147}.
Subcellular Location	Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.
Tissue Specificity	Ubiquitous. Highest expression seen in the heart and skeletal muscle.
Top Pathways	TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Smad1 siRNA I - 6223 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Smad1 siRNA II - 6227 from Cell Signaling Technology Category siRNA

Smad1 CRISPR/Cas9 KO Plasmid (h) - sc-400182 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Smad1 HDR Plasmid (h) - sc-400182-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smad1 Double Nickase Plasmid (h) - sc-400182-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smad1 Double Nickase Plasmid (h2) - sc-400182-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smad1 CRISPR Activation Plasmid (h) - sc-400182-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Smad1 CRISPR Activation Plasmid (h2) - sc-400182-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Smad1 Lentiviral Activation Particles (h) - sc-400182-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smad1 Lentiviral Activation Particles (h2) - sc-400182-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smad1 siRNA (h) - sc-29483 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Smad1 shRNA Plasmid (h) - sc-29483-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Smad1 shRNA (h) Lentiviral Particles - sc-29483-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU051601 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19749 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19749 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SMAD1 siRNA (Human) - CRH2769 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Smad1 RNAi - H00004086-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SMAD1 - MBS829894 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Smad1 (NM_005900.2) - SHH412948 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SMAD1(NM_001003688.1) - SHL015038 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human SMAD1(NM_005900.2) - SHL015074 from Creative biogene Category siRNA Species Reactivities Human

Human SMAD1 siRNA - orb263271 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SMAD1 shRNA Plasmid (Human) - CHH2769 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SMAD1 miRNA 3'UTR clone - MiUTR1H-09634 from Creative biogene Species Reactivities Human

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