Gene Symbol | CHCHD3 |
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Entrez Gene | 54927 |
Alt Symbol | MINOS3, PPP1R22 |
Species | Human |
Gene Type | protein-coding |
Description | coiled-coil-helix-coiled-coil-helix domain containing 3 |
Other Description | MICOS complex subunit MIC19|coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial|mitochondrial inner membrane organizing system 3|protein phosphatase 1, regulatory subunit 22 |
Swissprots | Q9NX63 |
Accessions | EAL24074 EAW83800 EAW83801 EAW83802 EAW83803 Q9NX63 AK000427 BAA91157 AK129533 AK294071 BAH11665 AK310236 BC011596 AAH11596 BC014839 AAH14839 HQ447383 ADQ31869 XM_011516363 XP_011514665 XM_011516364 XP_011514666 XM_011516365 XP_011514667 NM_017812 NP_060282 |
Function | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. {ECO:0000269|PubMed:22567091}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Intermembrane side {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:22567091}. Nucleus {ECO:0000269|PubMed:22567091}. |
Tissue Specificity | Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue. {ECO:0000269|PubMed:22567091}. |
Human CHCHD3 full length protein - ab171478 from Abcam
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Human CHCHD3 full length protein - ab162897 from Abcam
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CHCHD3 Antibody Blocking Peptide - LS-E27285 from LifeSpan Bioscience
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CHCHD3 Antibody Blocking Peptide - LS-E27286 from LifeSpan Bioscience
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CHCHD3 Antibody Blocking Peptide - LS-E20796 from LifeSpan Bioscience
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CHCHD3 Antibody Blocking Peptide - LS-E20795 from LifeSpan Bioscience
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CHCHD3 Recombinant Protein - H00054927-P01 from Novus Biologicals
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Recombinant Human CHCHD3 Protein - NBP2-22791 from Novus Biologicals
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CHCHD3 (aa151-164) blocking peptide - GTX88140-PEP from GeneTex
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CHCHD3 blocking peptide - GTX88139-PEP from GeneTex
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CHCHD3 Blocking Peptide - 33R-8063 from Fitzgerald
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CHCHD3 Blocking Peptide - 33R-5354 from Fitzgerald
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CHCHD3 protein (His tag) - 80R-3511 from Fitzgerald
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CHCHD3 Peptide - AC21-2105-P from Abcore
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CHCHD3 Peptide - AC21-2106-P from Abcore
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CHCHD3 (1-227, His-tag) - AR51201PU-N from Acris Antibodies
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CHCHD3 (1-227, His-tag) - AR51201PU-S from Acris Antibodies
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CHCHD3 - H00054927-P01-10 from Acris Antibodies
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CHCHD3 - H00054927-P01-25 from Acris Antibodies
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Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3, Human Recombinant - 228-13256-1 from RayBiotech
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CHCHD3, 1-227aa, Human, His tag, E.coli - 01-P2378 from ARP American Research Products
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CHCHD3 Peptide - 42-517P from ProSci
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CHCHD3 Peptide - 42-516P from ProSci
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CHCHD3 fusion protein - Ag22579 from Proteintech Group
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Recombinant Human coiled-coil-helix-coiled-coil-helix domain containing 3, His-tagged - CHCHD3-295H from Creative Biomart
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