BABAM1

Gene Symbol BABAM1
Entrez Gene 29086
Alt Symbol C19orf62, HSPC142, MERIT40, NBA1
Species Human
Gene Type protein-coding
Description BRISC and BRCA1 A complex member 1
Other Description BRCA1-A complex subunit MERIT40|BRISC and BRCA1-A complex member 1|mediator of RAP80 interactions and targeting subunit of 40 kDa|mediator of Rap80 interactions and targeting 40 kDa|new component of the BRCA1 A complex|new component of the BRCA1-A complex|new component of the BRCAA1 A complex
Swissprots Q9P018 Q6FIA0 B4DRY9 B4DVR1 A8MQT0 Q9NWV8
Accessions EAW84584 EAW84585 Q9NWV8 AF161491 AAF29106 AI948445 AJ572521 AK000578 BAA91268 AK025970 AK225047 AK301193 BAG62773 AK308590 AL136692 CAB66627 AM393637 CAL38513 AM393724 CAL38600 BC000788 AAH00788 BC006244 AAH06244 BC091491 AAH91491 BP246573 CR533526 CAG38557 CX866662 NM_001033549 NP_001028721 NM_001288756 NP_001275685 NM_001288757 NP_001275686 NM_014173 NP_054892
Function Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
Subcellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).

C19orf62-Over-expression-Lysate - LY10805a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag C19orf62 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the C19orf62 gene

HSPC142 293T Cell Transient Overexpression Lysate(Denatured) - H00029086-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

C19orf62 293 Cell Lysate - 409717 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

MERIT40/HSPC142 Overexpression Lysate (Native) - NBL1-08283 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: HSPC142 Overexpression Lysate (Adult Normal) [NBL1-08283] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HSPC142.

C19orf62 Over-expression Lysate Product - GWB-F09FD6 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

MERIT40/HSPC142 Overexpression Lysate (Native) - NBP2-10335 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: HSPC142 Overexpression Lysate (Adult Normal) [NBP2-10335] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HSPC142.

MERIT40/HSPC142 Overexpression Lysate (Denatured) - H00029086-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human BABAM1 Knockdown Stable Cell Line - CSC-DC001290 from Creative biogene

Category Cell Line
Species Human
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