| Gene Symbol |
DDX1
|
| Entrez Gene |
1653
|
| Alt Symbol |
DBP-RB, UKVH5d
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEAD (Asp-Glu-Ala-Asp) box helicase 1
|
| Other Description |
ATP-dependent RNA helicase DDX1|DEAD (Asp-Glu-Ala-Asp) box polypeptide 1|DEAD box polypeptide 1|DEAD box protein 1|DEAD box protein retinoblastoma|DEAD box-1|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
|
| Swissprots |
B4DPN6 B4DME8 Q92499
|
| Accessions |
EAX00894 EAX00895 EAX00896 EAX00897 EAX00898 Q92499 AB593031 BAJ83985 AB593032 BAJ83986 AB593033 BAJ83987 AB593034 BAJ83988 AK297432 BAG59860 AK298212 BAG60482 AK298426 BAG60648 AK313933 BAG36652 BC012132 AAH12132 BC012739 BC053673 AAH53673 DC360930 EF418570 ABN70940 EF418571 ABN70941 X70649 CAA49992 NM_004939 NP_004930
|
| Function |
Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF- kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermed
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasmic granule. Note=Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR- induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM- dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells. Required for proper localization of HIV-1 Rev. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269|PubMed:24608264}.
|
| Tissue Specificity |
Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord. {ECO:0000269|PubMed:7689221}.
|
![Western Blot: DDX1 Overexpression Lysate (Adult Normal) [NBL1-09780] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DDX1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1259_DDX1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09780-img0002.jpg)