DDX1

Gene Symbol	DDX1
Entrez Gene	1653
Alt Symbol	DBP-RB, UKVH5d
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 1
Other Description	ATP-dependent RNA helicase DDX1|DEAD (Asp-Glu-Ala-Asp) box polypeptide 1|DEAD box polypeptide 1|DEAD box protein 1|DEAD box protein retinoblastoma|DEAD box-1|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
Swissprots	B4DPN6 B4DME8 Q92499
Accessions	EAX00894 EAX00895 EAX00896 EAX00897 EAX00898 Q92499 AB593031 BAJ83985 AB593032 BAJ83986 AB593033 BAJ83987 AB593034 BAJ83988 AK297432 BAG59860 AK298212 BAG60482 AK298426 BAG60648 AK313933 BAG36652 BC012132 AAH12132 BC012739 BC053673 AAH53673 DC360930 EF418570 ABN70940 EF418571 ABN70941 X70649 CAA49992 NM_004939 NP_004930
Function	Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF- kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermed
Subcellular Location	Nucleus. Cytoplasm. Cytoplasmic granule. Note=Localized with MBNL1, TIAL1 and YBX1 in stress granules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalized into multiple foci (IR- induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomal DNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM- dependent manner after IR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Relocalized to the cytoplasm with a perinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells. Required for proper localization of HIV-1 Rev. Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269|PubMed:24608264}.
Tissue Specificity	Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord. {ECO:0000269|PubMed:7689221}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDX1 full length protein - ab114880 from Abcam Category Protein Source Wheat germ Species Human

Human DDX1 peptide - ab30615 from Abcam Category Peptide

Human DDX1 protein fragment - ab158270 from Abcam Category Protein Source Wheat germ Species Human

DDX1 Antibody Blocking Peptide - LS-E13027 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX1 Antibody Blocking Peptide - LS-E13028 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX1 Partial Recombinant Protein - H00001653-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DDX1 Blocking Peptide - 33R-8730 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDX1 Blocking Peptide - 33R-4046 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDX1 Blocking Peptide - 33R-4386 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DDX1 - H00001653-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

DDX1 - H00001653-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DDX1 - H00001653-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DDX1 fusion protein - Ag16774 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DDX1 fusion protein - ag1887 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DDX1 - DDX1-26545TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human DDX1, His-tagged - DDX1-11888H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human ATP-dependent RNA helicase DDX1(DDX1) - CSB-YP856393HU CSB-EP856393HU CSB-BP856393HU CSB-MP856393HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human DDX1 Protein - H00001653-P01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DDX1 - TP308769 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ATP-dependent RNA helicase DDX1 (DDX1) , Recombinant Protein - MBS1472969 from MyBioSource Category Protein Prices $2,670.00, $2,670.00, $3,090.00, $3,090.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

DDX1 Recombinant Protein Antigen - NBP1-85294PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DDX1 Recombinant Protein Antigen - NBP1-85293PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DDX1-Antibody-N-term-Blocking-Peptide - BP9683a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDX1 Peptide, Human - M34GP04134H from Creative Peptides Category Peptide Source Synthetic. Species Human

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