FZD5

Gene Symbol	FZD5
Entrez Gene	7855
Alt Symbol	C2orf31, HFZ5
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 5
Other Description	Wnt receptor|frizzled 5, seven transmembrane spanning receptor|frizzled family receptor 5|frizzled-5|fz-5|fzE5|seven-transmembrane receptor frizzled-5
Swissprots	B2RCZ1 A8K2X1 Q13467 Q53R22
Accessions	AAY24058 EAW70426 Q13467 AB043702 BAB60959 AK000125 AK024850 AK315338 BAG37738 AL136852 CAB66786 BC035962 BC048322 BC058895 BC095474 BC114346 BC156524 AAI56525 BC172518 AAI72518 BF059357 CR533442 CAG38473 U43318 AAC50385 NM_003468 NP_003459 NM_030804
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. {ECO:0000269|PubMed:10097073}.
Subcellular Location	Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250}.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Frizzled 5 peptide - ab134673 from Abcam Category Peptide Prices $176.00 Sizes 200 µg

Human Frizzled 5 full length protein - ab152825 from Abcam Category Protein Source Wheat germ Species Human

Human Frizzled 5 protein fragment - ab152826 from Abcam Category Protein Source Wheat germ Species Human

FZD5 / Frizzled 5 Antibody Blocking Peptide - LS-E3073 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZD5 / Frizzled 5 Antibody Blocking Peptide - LS-E28934 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD5 / Frizzled 5 Antibody Blocking Peptide - LS-E28935 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD5 / Frizzled 5 Antibody Blocking Peptide - LS-E28937 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD5 / Frizzled 5 Antibody Blocking Peptide - LS-E15164 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Frizzled-5 Protein - H00007855-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Frizzled-5 Recombinant Protein - H00007855-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FZD5-Antibody-C-term-Blocking-Peptide - BP14210b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Frizzled-5 Fc Chimera, CF - 1617-FZ-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human Frizzled-5 Fc Chimera, CF (CHO-expressed) - 1617-FZC-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Human C2orf31 protein - orb83707 from Biorbyt Category Protein Prices $434.00, $646.00 Sizes 50 μg, 100 μg Source Human Species Human

Human C2orf31 protein - orb83005 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

FZD5 Blocking Peptide - 33R-1836 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FZD5 Blocking Peptide - 33R-8742 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FZD5 / Frizzled-5 - H00007855-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FZD5 / Frizzled-5 - H00007855-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FZD5 / Frizzled-5 - H00007855-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FZD5 / Frizzled-5 - H00007855-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Frizzled 5 Recombinant Protein - 96-334 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

FZD5 fusion protein - Ag17354 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

FZD5 fusion protein - Ag16082 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human FZD5, Fc-His tagged - FZD5-713H from Creative Biomart Category Protein Source Human Cells Species Human

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