| Gene Symbol | Eef1a1 |
|---|---|
| Entrez Gene | 171361 |
| Alt Symbol | EEF-1, EEF1A, EF1A, Eef1a2, Eef1a2l1, SI |
| Species | Rat |
| Gene Type | protein-coding |
| Description | eukaryotic translation elongation factor 1 alpha 1 |
| Other Description | EF-1 alpha2|EF-1-alpha-1|EF-Tu|eEF1A-1|elongation factor 1 A-1|elongation factor 1-alpha 1|elongation factor Tu|eukaryotic elongation factor 1 A-1|eukaryotic translation elongation factor 1 alpha 2 like 1 |
| Swissprots | Q64718 P20001 P62630 Q78ED4 Q5BJW8 |
| Accessions | EDL77723 P62630 BC063162 AAH63162 BC072542 AAH72542 BC091297 AAH91297 BC111707 AAI11708 BC128723 AAI28724 L10339 AAA91895 M81088 AAA41105 X61043 CAA43378 X63561 CAA45122 NM_175838 NP_787032 |
| Function | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleolus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (By similarity). {ECO:0000250}. |
| Top Pathways | RNA transport, Legionellosis |