TSC2

Gene Symbol	TSC2
Entrez Gene	7249
Alt Symbol	LAM, PPP1R160, TSC4
Species	Human
Gene Type	protein-coding
Description	tuberous sclerosis 2
Other Description	protein phosphatase 1, regulatory subunit 160|tuberin|tuberous sclerosis 2 protein
Swissprots	B7Z2B8 B4DRN2 P49815 A7E2E2 B4DIQ7 B4DIL8 O75275 Q8TAZ1 Q4LE71 C9J378
Accessions	AAB41564 AAC34210 BAA32694 EAW85556 EAW85557 EAW85558 EAW85559 EAW85560 P49815 AB210000 BAE06082 AK022401 AK094152 BAG52831 AK125096 BAG54139 AK294548 BAH11804 AK295672 BAG58530 AK295728 BAG58569 AK299343 BAG61344 BC025364 AAH25364 BC046929 AAH46929 BC150300 AAI50301 BF194994 BM966762 BX647816 CAI46010 DA316794 DB288276 KJ534954 AHW56594 KJ534955 AHW56595 KJ534956 AHW56596 KJ534957 AHW56597 KJ534958 AHW56598 KJ534982 AHW56622 KJ534983 AHW56623 KJ534984 AHW56624 KJ534985 AHW56625 KJ535011 AHW56650 KJ535022 AHW56661 KJ535038 AHW56677 KJ535039 AHW56678 KJ535051 AHW56690 KJ535091 AHW56730 KJ535094 AHW56733 S82474 AAB37376 X75621 CAA53287 XM_005255529 XP_005255586 XM_005255531 XP_005255588 XM_011522636 XP_011520938 XM_011522637 XP_011520939 XM_011522638 XP_011520940 XM_011522639 XP_011520941 XM_011522640 XP_011520942 XM_011522641 XP_011520943 NM_000548 NP_000539 NM_001077183 NP_001070651 NM_001114382 NP_001107854 NM_021055 NM_021056
Function	In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. {ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16707451}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Tissue Specificity	Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
Top Pathways	p53 signaling pathway, Insulin signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Choline metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Tuberin/TSC2 siRNA II - 6548 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Tuberin/TSC2 siRNA I - 6476 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (50-100 transfections) Species Reactivities Human

tuberin CRISPR/Cas9 KO Plasmid (h) - sc-400683 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

tuberin HDR Plasmid (h) - sc-400683-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tuberin Double Nickase Plasmid (h) - sc-400683-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tuberin Double Nickase Plasmid (h2) - sc-400683-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tuberin CRISPR Activation Plasmid (h) - sc-400683-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

tuberin CRISPR Activation Plasmid (h2) - sc-400683-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

tuberin Lentiviral Activation Particles (h) - sc-400683-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tuberin Lentiviral Activation Particles (h2) - sc-400683-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

tuberin siRNA (h) - sc-36762 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

tuberin shRNA Plasmid (h) - sc-36762-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

tuberin shRNA (h) Lentiviral Particles - sc-36762-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TSC2 RNAi - H00007249-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN1074 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1074 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TSC2 siRNA (Human) - CRH4954 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TSC2 RNAi - H00007249-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TSC2 - MBS8219747 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TSC2(NM_000548.3) - SHL098382 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TSC2(NM_001077183.1) - SHL098400 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Danio rerio TSC2 (NM_001077183) - SHW010519 from Creative biogene Category siRNA Species Reactivities Zebrafish

shRNA set against Danio rerio TSC2 (NM_001114382) - SHW012272 from Creative biogene Category siRNA Species Reactivities Zebrafish

Human TSC2 siRNA - orb265456 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TSC2 shRNA Plasmid (Human) - CHH4954 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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