C5AR1

Gene Symbol C5AR1
Entrez Gene 728
Alt Symbol C5A, C5AR, C5R1, CD88
Species Human
Gene Type protein-coding
Description complement component 5a receptor 1
Other Description C5a anaphylatoxin chemotactic receptor 1|C5a anaphylatoxin receptor|C5a ligand|C5a-R|complement component 5 receptor 1
Swissprots P21730
Accessions AAD14919 AAO65969 CAB37830 EAW57470 EAW57471 P21730 BC008982 AAH08982 BE042476 BI916506 BM830753 BT007358 AAP36022 DQ891757 ABM82683 DQ894940 ABM85866 M62505 AAA62831 X57250 CAA40530 XM_005259190 XP_005259247 XM_011527247 XP_011525549 NM_001736 NP_001727
Function Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12464600}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269|PubMed:12464600}.
Top Pathways Complement and coagulation cascades, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction

CD88 (B-6) - sc-271949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD88 (B-6): sc-271949. Western blot analysis of CD88 expression in non-transfected: sc-117752 (A) and human CD88 transfected: sc-175352 (B) 293T whole cell lysates.

CD88 (C-19) - sc-7089 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD88 (C-19): sc-7089. Western blot analysis of CD88 expression in HeLa whole cell lysate.

CD88 (H-100) - sc-25774 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD88 (H-100): sc-25774. Western blot analysis of CD88 expression in U-937 (A) and HL-60/Mx-1 (B) whole cell lysates.

CD88 (8D6) - sc-53788 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD88 (8D6): sc-53788. Western blot analysis of CD88 expression in non-transfected: sc-110760 (A) and human CD88 transfected: sc-110903 (B) 293 whole cell lysates.

CD88 (N-20) - sc-31236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD88 (N-20): sc-31236. Western blot analysis of CD88 expression in non-transfected: sc-117752 (A) and human CD88 transfected: sc-175352 (B) 293T whole cell lysates.

CD88 (V-16) - sc-31237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CD88 (P12/1) - sc-53794 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD88 (P12/1): sc-53794. Indirect FCM analysis of human peripheral blood leukocytes stained with CD88 (P12/1), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>2a</sub>: sc-3878

CD88 (R63) - sc-53797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD88 (R63): sc-53797. Indirect FCM analysis of rat peripheral blood leukocytes stained with CD88 (R63), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877

CD88 (S5/1) - sc-53795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD88 (S5/1): sc-53795. Western blot analysis of CD88 expression in non-transfected: sc-117752 (A) and human CD88 transfected: sc-158362 (B) 293T whole cell lysates.

CD88 (W17/1) - sc-53796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

CD88 (3H1740) - sc-70813 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD88 (3H1740): sc-70813. Western blot analysis of CD88 expression in non-transfected: sc-117752 (A) and human CD88 transfected: sc-175352 (B) 293T whole cell lysates.

p-CD88 (32-G1) - sc-53793 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-CD88 (32-G1): sc-53793. Western blot analysis of CD88 phosphorylation in non-transfected: sc-117752 (A) and human CD88 transfected: sc-175352 (B) 293T whole cell lysates.

Anti-C5R1 (phospho S338) antibody - ab61022 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human brain tissue using ab61022 with (right) and without (left) the presence of the immunizing peptide.

Anti-C5R1 antibody - ab59390 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-C5R1 antibody (ab59390) at 1/500 dilutionLane 1 : Extracts from HeLa cells, treated with PMA (125ng/ml, 30mins).Lane 2 : Extracts from HeLa cells, treated with PMA (125ng/ml, 30mins) plus peptide.

Anti-C5R1 antibody - ab107011 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-C5R1 antibody (ab107011) at 1/100 dilution + A549 cell line lysate at 35 µg

Anti-C5R1 antibody - ab115296 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115296, at 10µg/ml, staining C5AR1 in Formalin-fixed, Paraffin-embedded Human placenta tissue by Immunohistochemistry followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-C5R1 antibody [P12/1] - ab24036 from Abcam

Prices $373.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone P12/1

Anti-C5R1 antibody [P12/1] - ab33212 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone P12/1
FACS analysis of C5R1 expressing cells in human peripheral blood granulocytes using ab33212.

Anti-C5R1 antibody [S5/1] - ab11867 from Abcam

Prices $390.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone S5/1
Human peripheral blood granulocytes stained with ab11867 (red line). Human whole blood was processed using a modified protocol based on Chow et al, 2005 (PMID: 16080188). In brief, human whole blood was fixed in 4% formaldehyde (methanol-free) for 10 min at 22°C. Red blood cells were then lyzed by the addition of Triton X-100 (final concentration - 0.1%) for 15 min at 37°C. For experimentation, cells were treated with 50% methanol (-20°C) for 15 min at 4°C. Cells were then incubated with the antibody (ab11867, 1μg/1x106 cells) for 30 min at 4°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 4°C. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >30,000 total events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. Gating strategy - periphera

Anti-C5R1 antibody [W17/1] - ab11884 from Abcam

Prices $372.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone W17/1

Anti-C5AR1 / CD88 / C5a Receptor Antibody - LS-C44866 from LifeSpan Bioscience

Prices $325.00
Sizes 250 µg
Host Rat
Clonality Monoclonal

Anti-C5AR1 / CD88 / C5a Receptor Antibody (RPE) - LS-C44562 from LifeSpan Bioscience

Prices $375.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-C5AR1 / CD88 / C5a Receptor Antibody (Biotin) - LS-C44867 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-C5AR1 / CD88 / C5a Receptor Antibody (Low Endotoxin) - LS-C44871 from LifeSpan Bioscience

Prices $435.00
Sizes 500 µg
Host Rat
Clonality Monoclonal

Anti-C5AR1 / CD88 / C5a Receptor Antibody - LS-C44872 from LifeSpan Bioscience

Prices $235.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
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