C5AR1

Gene Symbol	C5AR1
Entrez Gene	728
Alt Symbol	C5A, C5AR, C5R1, CD88
Species	Human
Gene Type	protein-coding
Description	complement component 5a receptor 1
Other Description	C5a anaphylatoxin chemotactic receptor 1|C5a anaphylatoxin receptor|C5a ligand|C5a-R|complement component 5 receptor 1
Swissprots	P21730
Accessions	AAD14919 AAO65969 CAB37830 EAW57470 EAW57471 P21730 BC008982 AAH08982 BE042476 BI916506 BM830753 BT007358 AAP36022 DQ891757 ABM82683 DQ894940 ABM85866 M62505 AAA62831 X57250 CAA40530 XM_005259190 XP_005259247 XM_011527247 XP_011525549 NM_001736 NP_001727
Function	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12464600}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269|PubMed:12464600}.
Top Pathways	Complement and coagulation cascades, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human C5a / C5a des Arg protein fragment - ab91017 from Abcam Category Protein Prices $520.00 Sizes 50 µg Source E. coli Species Human

Human C5R1 full length protein - ab157989 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human C5R1 full length protein - ab157990 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human C5R1 protein fragment - ab157991 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

C5AR1 / CD88 / C5a Receptor Antibody Blocking Peptide - LS-E422 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

C5AR1 / CD88 / C5a Receptor Antibody Blocking Peptide - LS-E28829 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

C5AR1 / CD88 / C5a Receptor Antibody Blocking Peptide - LS-E28831 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

C5AR1 / CD88 / C5a Receptor Blocking Peptide - LS-E21996 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Complement Component C5a R1 Protein - H00000728-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Complement Component C5a R1 Protein - H00000728-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Complement Component C5a R1 Protein - H00000728-P02 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Complement Component C5a R1 Protein - NBP1-99968 from Novus Biologicals Category Protein

Recombinant Human Complement Component C5a R1 Protein - NBP1-99902 from Novus Biologicals Category Protein Prices $205.00 Sizes 20 µg Source E. coli Species Human

Recombinant Human Complement Component C5a R1 Protein - NBP1-99516 from Novus Biologicals Category Protein Prices $205.00 Sizes 20 µg Source E. coli Species Human

Complement Component C5a R1 Protein - NBP1-99732 from Novus Biologicals Category Protein

C5AR1-Antibody-Center-Blocking-peptide - BP10701c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

C5a (His-Tag) recombinant protein - GTX65515 from GeneTex Category Protein Prices $249.00 Sizes 20 μg Source E. coli Species Human

C5a recombinant protein - GTX65516 from GeneTex Category Protein Prices $269.00 Sizes 20 μg Source E. coli Species Human

C5a Protein (OPPA00056) - OPPA00056 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Escherichia Coli.

Mouse C5a protein - orb168027 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Mouse

C5a protein - 30R-2807 from Fitzgerald Category Protein Prices $280.00 Sizes 20 µg Source E.coli Species Human

C5a protein (His tag) - 80R-2548 from Fitzgerald Category Protein Prices $295.00 Sizes 20 µg Source E.coli Species Human

C5AR1 Blocking Peptide - 33R-8506 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CD88 / C5R1 - H00000728-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

CD88 / C5R1 - H00000728-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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