C5AR1

Gene Symbol C5AR1
Entrez Gene 728
Alt Symbol C5A, C5AR, C5R1, CD88
Species Human
Gene Type protein-coding
Description complement component 5a receptor 1
Other Description C5a anaphylatoxin chemotactic receptor 1|C5a anaphylatoxin receptor|C5a ligand|C5a-R|complement component 5 receptor 1
Swissprots P21730
Accessions AAD14919 AAO65969 CAB37830 EAW57470 EAW57471 P21730 BC008982 AAH08982 BE042476 BI916506 BM830753 BT007358 AAP36022 DQ891757 ABM82683 DQ894940 ABM85866 M62505 AAA62831 X57250 CAA40530 XM_005259190 XP_005259247 XM_011527247 XP_011525549 NM_001736 NP_001727
Function Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12464600}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:12464600}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269|PubMed:12464600}.
Top Pathways Complement and coagulation cascades, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction

CD88 CRISPR/Cas9 KO Plasmid (h) - sc-401968 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD88 HDR Plasmid (h) - sc-401968-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD88 Double Nickase Plasmid (h) - sc-401968-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD88 Double Nickase Plasmid (h2) - sc-401968-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD88 CRISPR Activation Plasmid (h) - sc-401968-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD88 CRISPR Activation Plasmid (h2) - sc-401968-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD88 Lentiviral Activation Particles (h) - sc-401968-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD88 Lentiviral Activation Particles (h2) - sc-401968-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD88 siRNA (h) - sc-35031 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD88 shRNA Plasmid (h) - sc-35031-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD88 shRNA (h) Lentiviral Particles - sc-35031-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Complement Component C5a R1 RNAi - H00000728-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU021841 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4967 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4967 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09066 from Sigma-Aldrich

Category miRNA

C5AR1 siRNA (Human) - CRH0505 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C5AR1 - MBS8223878 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human C5AR1 (NM_001736.3) - SHH251969 from Creative biogene

Category siRNA
Species Reactivities Human

Human C5AR1 siRNA - orb261007 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C5AR1 shRNA Plasmid (Human) - CHH0505 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

C5AR1 miRNA 3'UTR clone - MiUTR1H-01417 from Creative biogene

Species Reactivities Human
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