| Gene Symbol |
TBL1XR1
|
| Entrez Gene |
79718
|
| Alt Symbol |
C21, DC42, IRA1, TBLR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transducin (beta)-like 1 X-linked receptor 1
|
| Other Description |
F-box-like/WD repeat-containing protein TBL1XR1|TBL1-related protein 1|nuclear receptor co-repressor/HDAC3 complex subunit|nuclear receptor corepressor/HDAC3 complex subunit TBLR1|transducin beta-like 1X-related protein 1
|
| Swissprots |
Q9H2I1 Q14DC3 Q9BZK7 Q9H9A1 D3DNQ9
|
| Accessions |
EAW78437 EAW78438 EAW78439 Q9BZK7 AF086399 AF267864 AAG44733 AF268193 AAG44736 AF314544 AAK00301 AK022956 BAB14331 AK025746 AK296946 BAH12461 AL598314 BC034712 BC048298 AAH48298 BC060320 AAH60320 BC070134 BC092400 BC113421 AAI13422 BX648080 BX648935 DB459301 HQ258622 ADR83374 XM_005247771 XP_005247828 XM_005247772 XP_005247829 XM_005247775 XP_005247832 XM_005247776 XP_005247833 XM_006713745 XP_006713808 XM_006713746 XP_006713809 XM_011513140 XP_011511442 XM_011513141 XP_011511443 XM_011513142 XP_011511444 XM_011513143 XP_011511445 NM_024665 NP_078941
|
| Function |
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. {ECO:0000269|PubMed:14980219}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Wnt signaling pathway
|