Gene Symbol | TBL1XR1 |
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Entrez Gene | 79718 |
Alt Symbol | C21, DC42, IRA1, TBLR1 |
Species | Human |
Gene Type | protein-coding |
Description | transducin (beta)-like 1 X-linked receptor 1 |
Other Description | F-box-like/WD repeat-containing protein TBL1XR1|TBL1-related protein 1|nuclear receptor co-repressor/HDAC3 complex subunit|nuclear receptor corepressor/HDAC3 complex subunit TBLR1|transducin beta-like 1X-related protein 1 |
Swissprots | Q9H2I1 Q14DC3 Q9BZK7 Q9H9A1 D3DNQ9 |
Accessions | EAW78437 EAW78438 EAW78439 Q9BZK7 AF086399 AF267864 AAG44733 AF268193 AAG44736 AF314544 AAK00301 AK022956 BAB14331 AK025746 AK296946 BAH12461 AL598314 BC034712 BC048298 AAH48298 BC060320 AAH60320 BC070134 BC092400 BC113421 AAI13422 BX648080 BX648935 DB459301 HQ258622 ADR83374 XM_005247771 XP_005247828 XM_005247772 XP_005247829 XM_005247775 XP_005247832 XM_005247776 XP_005247833 XM_006713745 XP_006713808 XM_006713746 XP_006713809 XM_011513140 XP_011511442 XM_011513141 XP_011511443 XM_011513142 XP_011511444 XM_011513143 XP_011511445 NM_024665 NP_078941 |
Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. {ECO:0000269|PubMed:14980219}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Wnt signaling pathway |
TBL1XR1 CRISPR/Cas9 KO Plasmid (h) - sc-401998 from Santa Cruz Biotechnology
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TBL1XR1 HDR Plasmid (h) - sc-401998-HDR from Santa Cruz Biotechnology
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TBL1XR1 Double Nickase Plasmid (h) - sc-401998-NIC from Santa Cruz Biotechnology
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TBL1XR1 Double Nickase Plasmid (h2) - sc-401998-NIC-2 from Santa Cruz Biotechnology
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TBL1XR1 CRISPR Activation Plasmid (h) - sc-401998-ACT from Santa Cruz Biotechnology
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TBL1XR1 CRISPR Activation Plasmid (h2) - sc-401998-ACT-2 from Santa Cruz Biotechnology
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TBL1XR1 Lentiviral Activation Particles (h) - sc-401998-LAC from Santa Cruz Biotechnology
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TBL1XR1 Lentiviral Activation Particles (h2) - sc-401998-LAC-2 from Santa Cruz Biotechnology
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TBL1XR1 siRNA (h) - sc-106601 from Santa Cruz Biotechnology
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TBL1XR1 shRNA Plasmid (h) - sc-106601-SH from Santa Cruz Biotechnology
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TBL1XR1 shRNA (h) Lentiviral Particles - sc-106601-V from Santa Cruz Biotechnology
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TBLR1 RNAi - H00079718-R01 from Novus Biologicals
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MISSION® esiRNA - EHU135571 from Sigma-Aldrich
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MISSION® esiRNA - EHU096761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21093 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21093 from Sigma-Aldrich
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TBL1XR1 siRNA (Human) - CRJ2511 from Cohesion Biosciences
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TBL1XR1 - MBS8227366 from MyBioSource
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TBL1XR1 CRISPR/Cas9 KO Plasmid (h2) - sc-401998-KO-2 from Santa Cruz Biotechnology
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TBL1XR1 HDR Plasmid (h2) - sc-401998-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TBL1XR1 (NM_024665.4) - SHH424228 from Creative biogene
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shRNA set against Human TBL1XR1(NM_024665.4) - SHL041978 from Creative biogene
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Human TBL1XR1 siRNA - orb273012 from Biorbyt
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TBL1XR1 shRNA Plasmid (Human) - CHJ2511 from Cohesion Biosciences
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TBL1XR1 miRNA 3'UTR clone - MiUTR1H-10231 from Creative biogene
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