CEP290

Gene Symbol CEP290
Entrez Gene 80184
Alt Symbol 3H11Ag, BBS14, CT87, JBTS5, LCA10, MKS4, NPHP6, POC3, SLSN6, rd16
Species Human
Gene Type protein-coding
Description centrosomal protein 290kDa
Other Description Bardet-Biedl syndrome 14 protein|CTCL tumor antigen se2-2|Meckel syndrome, type 4|POC3 centriolar protein homolog|cancer/testis antigen 87|centrosomal protein of 290 kDa|monoclonal antibody 3H11 antigen|nephrocytsin-6|prostate cancer antigen T21|tumor antigen se2-2
Swissprots Q9H6Q7 Q66GS8 Q1PSK5 Q9H8I0 Q9H2G6 O15078
Accessions EAW97413 EAW97414 O15078 AB002371 BAA20828 AF273044 AAG34904 AF317887 AAK01919 AK023677 AK025632 BAB15196 AY590151 AAT01278 BC008641 AAH08641 BC043398 AAH43398 BC156462 AAI56463 BC172566 AAI72566 BK005587 DAA05591 BU676074 DQ109808 AAZ83370 XM_011538756 XP_011537058 XM_011538757 XP_011537059 XM_011538758 XP_011537060 XM_011538759 XP_011537061 XM_011538760 XP_011537062 XM_011538761 XP_011537063 XM_011538762 XP_011537064 XM_011538763 XP_011537065 XM_011538764 XP_011537066 XM_011538765 XP_011537067 XM_011538766 XP_011537068 NM_025114 NP_079390
Function Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. {ECO:0000250|UniProtKB:Q6A078, ECO:0000269|PubMed:16682973}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Connecting cilium of photoreceptor cells, base of cilium in kidney intramedullary collecting duct cells. Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity). Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}.
Tissue Specificity Ubiquitous. Expressed strongly in placenta and weakly in brain. {ECO:0000269|PubMed:11149944, ECO:0000269|PubMed:16682973}.

CEP290 (B-7) - sc-390462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CEP290 (B-7): sc-390462. Western blot analysis of CEP290 expression in CCRF-CEM whole cell lysate.

CEP290 (G-4) - sc-390637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CEP290 (G-4): sc-390637. Western blot analysis of CEP290 expression in CCRF-CEM whole cell lysate.

CEP290 (H-300) - sc-292138 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CEP290 (K-16) - sc-70030 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CEP290 (L-18) - sc-70031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CEP290 (L-18): sc-70031. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic and nuclear staining of glandular cells.

Anti-CEP290 antibody - ab85728 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of NBF-fixed asynchronous HeLa cells labelling CEP290 with ab85728 at 1/500. A DyLight® 594-conjugated goat anti-rabbit IgG (1/100) was used as the secondary antibody.

Anti-CEP290 antibody - ab84870 from Abcam

Prices $382.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Staining of human CEP290 in NBF fixed asynchronous HeLa cells by Immunocytochemistry, using ab84870 at a dilution of 1/250. Detection: Red fluorescent goat anti-rabbit IgG used at a dilution of 1/100.

Anti-CEP290 antibody - ab190237 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CEP290 antibody (ab190237) at 1/500 dilutionLane 1 : K562 cell extractLane 2 : K562 cell extract with synthesized peptide

Anti-CEP290 antibody - ab128231 from Abcam

Prices $373.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CEP290 antibody - ab110053 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CEP290 antibody (ab110053) at 1/500 dilutionLane 1 : K562 cell extractLane 2 : K562 cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CEP290 antibody - ab77479 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CEP290 Antibody (aa2429-2479) - LS-C288447 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human CEP290 by Immunocytochemistry. Sample: NBF-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-CEP290 used at a dilution of 1:500. Detection: Red-fluorescent goat anti-rabbit IgG cross-adsorbed Antibody DyLight 594 (A120-601D4) used at a dilution of 1:100.

Anti-CEP290 Antibody (aa2429-2479) - LS-C286600 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human CEP290 by Immunocytochemistry. Sample: NBF-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-CEP290 (-2) used at a dilution of 1:250. Detection: Red-fluorescent goat anti-rabbit IgG cross-adsorbed Antibody DyLight 594 (A120-601D4) used at a dilution of 1:100.

Anti-CEP290 Antibody (Phe812) - LS-C177808 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of CEP290 (F812) pAb in extracts from K562 cells.

Anti-CEP290 Antibody (aa771-820) IHC-plus™ - LS-B9714 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CEP290 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9714 concentration 10 ug/ml.

Anti-CEP290 Antibody (Internal) - LS-C61718 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CEP290 Antibody (Internal) - LS-C108890 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CEP290 Antibody (C-Terminus) - LS-C153392 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

CEP290 Antibody - NB100-86991 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CEP290 Antibody [NB100-86991] - Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. NB100-86991 used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.

CEP290 Antibody - NBP2-33406 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CEP290 Antibody - 44100002 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: CEP290 Antibody [44100002]

CEP290 Antibody - NBP1-52132 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunofluorescence: CEP290 Antibody [NBP1-52132] - Overnight staining of cell lines OPCT-1 (A) and MDA468 (fB) with Alexa Fluor 568 (red) and nuclear counter staining with DAPI (blue), provided by Dr S, McArdle, and obtained by Sumanjeet Malhi, John van Geest Research Centre, Nottingham, UK.

Anti-CEP290 antibody produced in rabbit - SAB4503198 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CEP290, C-Terminal: <B>Cat. No. SAB4503198</B>: Immunoblotting analysis of extracts from K562 cells, using Anti-CEP290, C-Terminal antibody. The lane on the left was treated with the Anti-CEP290, C-Terminal antibody. The lane on the right (negative control) was treated with both Anti-CEP290, C-Terminal antibody and the synthesized immunogen peptide.

Anti-CEP290 antibody produced in goat - SAB2501952 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-CEP290 <B>Cat. No. SAB2501952</B>: Immunofluorescence (2.5 μg/mL overnight staining of cell lines OPCT-1 (A) and MDA468 (fB) with Alexa Fluor 568 (red) and nuclear counter staining with DAPI (blue). Data provided by Dr. S. McArdle, and obtained by Sumanjeet Malhi, John van Geest Research Center.

Anti-CEP290 antibody produced in rabbit - HPA043918 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CEP290: <B>Cat. No. HPA043918</B>: Immunohistochemical staining of Human colon shows strong cytoplasmic positivity with a granular pattern in glandular cells.
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