Gene Symbol | Cyp1a2 |
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Entrez Gene | 13077 |
Alt Symbol | CP12, Cyp1a1, P450-3 |
Species | Mouse |
Gene Type | protein-coding |
Description | cytochrome P450, family 1, subfamily a, polypeptide 2 |
Other Description | CYPIA2|aromatic compound inducible|cytochrome P450 1A2|cytochrome P450 family 1 subfamily a polypeptide 1|cytochrome P450, 1a2, aromatic compound inducible|cytochrome P450-P2|cytochrome P450-P3 |
Swissprots | P00186 Q9QWJ4 |
Accessions | AAA37508 AAA39873 ACJ12938 CAA25837 EDL25920 P00186 BC018298 AAH18298 BC054827 AAH54827 K02589 AAA37509 X00479 CAA25156 X04283 CAA27832 NM_009993 NP_034123 |
Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism |
CYP1A2 CRISPR/Cas9 KO Plasmid (m) - sc-419898 from Santa Cruz Biotechnology
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CYP1A2 HDR Plasmid (m) - sc-419898-HDR from Santa Cruz Biotechnology
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CYP1A2 Double Nickase Plasmid (m) - sc-419898-NIC from Santa Cruz Biotechnology
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CYP1A2 Double Nickase Plasmid (m2) - sc-419898-NIC-2 from Santa Cruz Biotechnology
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CYP1A2 CRISPR Activation Plasmid (m) - sc-419898-ACT from Santa Cruz Biotechnology
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CYP1A2 CRISPR Activation Plasmid (m2) - sc-419898-ACT-2 from Santa Cruz Biotechnology
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CYP1A2 Lentiviral Activation Particles (m) - sc-419898-LAC from Santa Cruz Biotechnology
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CYP1A2 Lentiviral Activation Particles (m2) - sc-419898-LAC-2 from Santa Cruz Biotechnology
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CYP1A2 siRNA (m) - sc-41486 from Santa Cruz Biotechnology
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CYP1A2 shRNA Plasmid (m) - sc-41486-SH from Santa Cruz Biotechnology
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CYP1A2 shRNA (m) Lentiviral Particles - sc-41486-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN29494 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29494 from Sigma-Aldrich
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CYP1A2 siRNA (Mouse) - CRM0930 from Cohesion Biosciences
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CYP1A2 - MBS8234187 from MyBioSource
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shRNA set against Mouse CYP1A2 (NM_009993.3) - SHH272881 from Creative biogene
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shRNA set against Mouse Cyp1a2(NM_009993.3) - SHG215647 from Creative biogene
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Mouse CYP1A2 siRNA - orb280406 from Biorbyt
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CYP1A2 shRNA Plasmid (Mouse) - CHM0930 from Cohesion Biosciences
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CYP1A2 miRNA 3'UTR clone - MiUTR1M-03517 from Creative biogene
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