| Gene Symbol |
Pkdcc
|
| Entrez Gene |
106522
|
| Alt Symbol |
AI115348, AW548124, Adtk1, ESTM17, MAd1, Sgk493, Vlk, X83346
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
protein kinase domain containing, cytoplasmic
|
| Other Description |
extracellular tyrosine-protein kinase PKDCC|protein kinase domain-containing protein, cytoplasmic|protein kinase-like protein SgK493|sugen kinase 493|vertebrate lonesome kinase
|
| Swissprots |
Q3UZD3 Q5RJI4 Q8VBZ6 B6F136
|
| Accessions |
EDL38545 Q5RJI4 AB381893 BAH66379 AB436780 BAG82823 AK133913 BAE21924 BB804204 BC022157 AAH22157 BC086639 AAH86639 CJ178539 CK624551 XM_011246234 XP_011244536 NM_134117 NP_598878
|
| Function |
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). May also have serine/threonine protein kinase activity (PubMed:25171405). Required for longitudinal bone growth through regulation of chondrocyte differentiation (PubMed:19097194, PubMed:23792766). May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (PubMed:19465597). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). {ECO:0000269|PubMed:19097194, ECO:0000269|PubMed:19465597, ECO:0000269|PubMed:23792766, ECO:0000269|PubMed:25171405}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:25171405}. Golgi apparatus {ECO:0000269|PubMed:19465597}. Note=Both secreted and present in the Golgi apparatus. {ECO:0000269|PubMed:19465597, ECO:0000269|PubMed:25171405}.
|
| Tissue Specificity |
Strongly expressed in adult heart, liver and testis with weak expression in brain, spleen, lung and thymus. In the humerus, strongly expressed in early flat proliferative chondrocytes. In the embryo, expressed in the anterior visceral endoderm and anterior primitive streak at E6.5. At E7.5, expressed in the anterior definitive endoderm (ADE) and anterior mesoderm but not in the notochord. At E8.0, expressed in the ADE and anterior embryonic mesoderm. At E8.5, expressed more broadly in anterior tissues and at the midline of the neural plate in the midbrain region as well as the lateral margins of the neural plate posterior to the metencephalic region. Also weakly expressed in the anterior mesenchyme. At E9.5, strongest expression in branchial arches and limb buds. During mid-gestation, expression continues in mesenchymal cells, particularly in areas where these cells condense. {ECO:0000269|PubMed:19097194, ECO:0000269|PubMed:19465597}.
|