ACER2

Gene Symbol	ACER2
Entrez Gene	340485
Alt Symbol	ALKCDase2, ASAH3L
Species	Human
Gene Type	protein-coding
Description	alkaline ceramidase 2
Other Description	alkCDase 2|alkaline CDase 2|ceramide hydrolase|haCER2
Swissprots	A2A3R8 Q5VZR7 Q569G5 Q5QJU3 Q71RD2
Accessions	EAW58634 Q5QJU3 AF370405 AAQ15241 AK123581 BAG53917 AY312516 AAQ85132 BC092487 AAH92487 XM_005251447 XP_005251504 XM_005251448 XP_005251505 XM_011517856 XP_011516158 XM_011517857 XP_011516159 XM_011517858 XP_011516160 XM_011517859 XP_011516161 XR_242505 XR_242506 XR_242507 XR_929240 XR_929241 NM_001010887 NP_001010887
Function	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)- ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)- ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. {ECO:0000269|PubMed:16940153, E
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856}; Multi- pass membrane protein {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856}.
Tissue Specificity	Highly expressed in placenta. {ECO:0000269|PubMed:16940153}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Alkaline ceramidase 2 (ACER2), Human, ELISA Kit - E01A1189 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7227151 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7228433 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7227699 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7237200 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7211108 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7219819 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7246457 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7209609 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7241622 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7244971 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7212507 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline ceramidase 2 (ACER2), ELISA Kit - MBS7248869 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9312505 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.625 ng/ml - 20 ng/ml.

Human ACER2 ELISA Kit - E001374 from Biobool Category ELISA Kit

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394422 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394430 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394415 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394418 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394416 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394417 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394421 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394426 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394419 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Alkaline Ceramidase 2 (ACER2), ELISA Kit - MBS9394423 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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