KNG1

Gene Symbol	KNG1
Entrez Gene	3827
Alt Symbol	BDK, BK, KNG
Species	Human
Gene Type	protein-coding
Description	kininogen 1
Other Description	HMWK|alpha-2-thiol proteinase inhibitor|bradykinin|fitzgerald factor|high molecular weight kininogen|kininogen-1|williams-Fitzgerald-Flaujeac factor
Swissprots	B2RCR2 Q6PAU9 A8K474 Q53EQ0 P01042 P01043 C9JEX1 Q7M4P1
Accessions	AAB59550 AAB59551 AAO61092 CBN73461 EAW78179 EAW78180 EAW78181 P01042 AI133186 AK223589 BAD97309 AK290839 BAF83528 AK298440 BAG60660 AK303768 BAG64734 AK315230 BAG37659 BC026253 AAH26253 BC060039 AAH60039 BG430928 CB148843 CD014130 DA537547 DC362362 K02566 AAA35497 NM_000893 NP_000884 NM_001102416 NP_001095886 NM_001166451 NP_001159923
Function	(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood
Subcellular Location	Secreted, extracellular space.
Tissue Specificity	Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. {ECO:0000269|PubMed:2076202}.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Bradykinin ELISA kit - ab136936 from Abcam Category ELISA Kit Prices $573.00 Sizes 1 x 96 tests Sensitivity 24.8 pg/ml Range 11.7 pg/ml - 30000 pg/ml

HMW Kininogen Human SimpleStep ELISA™ Kit - ab189574 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 8.7 pg/ml Range 23 pg/ml - 1500 pg/ml

Kininogen (KNG) Human ELISA Kit - ab108875 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity > 0.1 µg/ml Range 0.125 µg/ml - 4 µg/ml

Kininogen (KNG) Human ELISA Kit - ab108876 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 1.5 ng/ml Range 1.563 ng/ml - 100 ng/ml

Human KNG1 / Kininogen / Bradykinin ELISA Kit (Sandwich ELISA) - LS-F4512 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.123 ng/ml Range 24.58-2400 ng/ml

Mouse KNG1 / Kininogen / Bradykinin ELISA Kit (Sandwich ELISA) - LS-F6981 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.25 ng/ml Range 24.58-2400 ng/ml

Human KNG1 / Kininogen / Bradykinin ELISA Kit (Sandwich ELISA) - LS-F10493 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 20 pg/ml Range 24.58-2400 ng/ml

Rat KNG1 / Kininogen / Bradykinin ELISA Kit (Sandwich ELISA) - LS-F7549 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 11.8 pg/ml Range 24.58-2400 ng/ml

Human KNG1 / Kininogen / Bradykinin ELISA Kit (Sandwich ELISA) - LS-F11899 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 1.56 Range 24.58-2400 ng/ml

Human Bradykinin ELISA Kit - abx150832 from Abbexa Category ELISA Kit Sensitivity 8.53 pg/ml Range 24.69 pg/ml - 2000 pg/ml

Human Bradykinin ELISA Kit - abx051631 from Abbexa Category ELISA Kit Sensitivity 0.05 ng/ml Range 0.2 ng/ml - 6 ng/ml

Human HMWK ELISA Kit - abx151830 from Abbexa Category ELISA Kit Sensitivity 0.132 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Kininogen 1 ELISA Kit - abx152131 from Abbexa Category ELISA Kit Sensitivity 0.114 ng/ml Range 0.313 ng/ml - 20 ng/ml

Bradykinin, BK, Human, ELISA Kit - E-EL-H0596 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Bradykinin, Human, ELISA Kit - E01B0664 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5.0-100ng/ml

High Molecular Weight Kininogen (HMWK), Human, ELISA Kit - SEB805Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.132ng/mL Range 0.312-20ng/mL

Kininogen 1 (KNG1), Human, ELISA Kit - SEB267Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 3.1pg/mL Range 7.8-500pg/mL

Kininogen-1 (KNG1), Human, ELISA Kit - CSB-EL012479HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Kininogen-1, KNG1, Human, ELISA Kit - E1805h from ARP American Research Products Category ELISA Kit Prices $576.00 Sizes 96 t Range 1.56-100 ng/mL

Kininogen 1, KNG1, Human, ELISA Kit - E-EL-H2255 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 4.688 Range 7.813-500pg/mL

Bradykinin, BK, Mouse, ELISA Kit - E-EL-M0202 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Bradykinin, BK, Rat, ELISA Kit - E-EL-R0124 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.75 Range 1.25-80ng/mL

Bradykinin, BK, Rabbit, ELISA Kit - E-EL-RB2218 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Kininogen 1, KNG1, Rabbit, ELISA Kit - E-EL-RB1818 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Bradykinin, BK, Chicken, ELISA Kit - E-EL-Ch1779 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

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