KNG1

Gene Symbol	KNG1
Entrez Gene	3827
Alt Symbol	BDK, BK, KNG
Species	Human
Gene Type	protein-coding
Description	kininogen 1
Other Description	HMWK|alpha-2-thiol proteinase inhibitor|bradykinin|fitzgerald factor|high molecular weight kininogen|kininogen-1|williams-Fitzgerald-Flaujeac factor
Swissprots	B2RCR2 Q6PAU9 A8K474 Q53EQ0 P01042 P01043 C9JEX1 Q7M4P1
Accessions	AAB59550 AAB59551 AAO61092 CBN73461 EAW78179 EAW78180 EAW78181 P01042 AI133186 AK223589 BAD97309 AK290839 BAF83528 AK298440 BAG60660 AK303768 BAG64734 AK315230 BAG37659 BC026253 AAH26253 BC060039 AAH60039 BG430928 CB148843 CD014130 DA537547 DC362362 K02566 AAA35497 NM_000893 NP_000884 NM_001102416 NP_001095886 NM_001166451 NP_001159923
Function	(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood
Subcellular Location	Secreted, extracellular space.
Tissue Specificity	Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. {ECO:0000269|PubMed:2076202}.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Bradykinin full length protein - ab182820 from Abcam Category Protein Prices $287.00 Sizes 50 µg Source E. coli Species Human

Human HMW Kininogen full length protein - ab90353 from Abcam Category Protein Source Native Species Human

Human HMW Kininogen full length protein - ab167823 from Abcam Category Protein Source Native Species Human

Human Kininogen 1 full length protein - ab158800 from Abcam Category Protein Source Wheat germ Species Human

Human Kininogen 1 full length protein - ab152032 from Abcam Category Protein Source HEK 293 cells Species Human

Human Kininogen 1 protein fragment - ab158801 from Abcam Category Protein Source Wheat germ Species Human

Human LMW Kininogen full length protein - ab91118 from Abcam Category Protein Source Native Species Human

Human LMW Kininogen full length protein - ab167808 from Abcam Category Protein Source Native Species Human

KNG1 / Kininogen / Bradykinin Antibody Blocking Peptide - LS-E1150 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KNG1 / Kininogen / Bradykinin Antibody Blocking Peptide - LS-E16679 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KNG1 / Kininogen / Bradykinin Antibody Blocking Peptide - LS-E21652 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HMW Kininogen Protein - H00003827-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HMW Kininogen Protein - H00003827-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KNG1-Antibody-N-term-Blocking-peptide - BP11683a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Bradykinin - SP2120b from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 20 mg

Bradykinin - SP2120a from Abgent, a WuXi AppTec company Category Peptide Prices $200.00 Sizes 10 mg

Bradykinin - SP2391b from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 20 mg

Bradykinin - SP2391a from Abgent, a WuXi AppTec company Category Peptide Prices $200.00 Sizes 10 mg

Recombinant Human Kininogen HMW (HKa), CF - 1569-PI-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln19-Ser644, with an N-terminal signal sequence and a C-terminal 10-His tag

Recombinant Human Kininostatin - 1396-KN-050 from R&D Systems Category Protein Source E. coli-derived, Lys438-Ser531

Recombinant Human Kininostatin, CF - 1396-KN-050/CF from R&D Systems Category Protein Source E. coli-derived, Lys438-Ser531

Recombinant human Kininogen-1 protein (OPCA01043) - OPCA01043 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

SYNTHETIC Human BRADYKININ Protein (OPSA10470) - OPSA10470 from Aviva Systems Biology Category Protein Prices $115.00 Sizes 1 mg Species Human

SYNTHETIC Human KALLIDIN II Protein (OPSA10471) - OPSA10471 from Aviva Systems Biology Category Protein Prices $160.00 Sizes 5 mg Species Human

NATIVE Human KININOGEN HMW DOUBLE CHAIN Protein (OPSA10546) - OPSA10546 from Aviva Systems Biology Category Protein Prices $245.00 Sizes 100 µg Species Human

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