KNG1
| Gene Symbol | KNG1 |
|---|---|
| Entrez Gene | 3827 |
| Alt Symbol | BDK, BK, KNG |
| Species | Human |
| Gene Type | protein-coding |
| Description | kininogen 1 |
| Other Description | HMWK|alpha-2-thiol proteinase inhibitor|bradykinin|fitzgerald factor|high molecular weight kininogen|kininogen-1|williams-Fitzgerald-Flaujeac factor |
| Swissprots | B2RCR2 Q6PAU9 A8K474 Q53EQ0 P01042 P01043 C9JEX1 Q7M4P1 |
| Accessions | AAB59550 AAB59551 AAO61092 CBN73461 EAW78179 EAW78180 EAW78181 P01042 AI133186 AK223589 BAD97309 AK290839 BAF83528 AK298440 BAG60660 AK303768 BAG64734 AK315230 BAG37659 BC026253 AAH26253 BC060039 AAH60039 BG430928 CB148843 CD014130 DA537547 DC362362 K02566 AAA35497 NM_000893 NP_000884 NM_001102416 NP_001095886 NM_001166451 NP_001159923 |
| Function | (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood |
| Subcellular Location | Secreted, extracellular space. |
| Tissue Specificity | Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. {ECO:0000269|PubMed:2076202}. |
| Top Pathways | Complement and coagulation cascades |
Bradykinin CRISPR/Cas9 KO Plasmid (h) - sc-402422 from Santa Cruz Biotechnology
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Bradykinin HDR Plasmid (h) - sc-402422-HDR from Santa Cruz Biotechnology
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Bradykinin Double Nickase Plasmid (h) - sc-402422-NIC from Santa Cruz Biotechnology
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Bradykinin Double Nickase Plasmid (h2) - sc-402422-NIC-2 from Santa Cruz Biotechnology
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Bradykinin CRISPR Activation Plasmid (h) - sc-402422-ACT from Santa Cruz Biotechnology
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Bradykinin CRISPR Activation Plasmid (h2) - sc-402422-ACT-2 from Santa Cruz Biotechnology
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Bradykinin Lentiviral Activation Particles (h) - sc-402422-LAC from Santa Cruz Biotechnology
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Bradykinin Lentiviral Activation Particles (h2) - sc-402422-LAC-2 from Santa Cruz Biotechnology
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Kininogen siRNA (h) - sc-40723 from Santa Cruz Biotechnology
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Kininogen shRNA Plasmid (h) - sc-40723-SH from Santa Cruz Biotechnology
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Kininogen shRNA (h) Lentiviral Particles - sc-40723-V from Santa Cruz Biotechnology
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HMW Kininogen RNAi - H00003827-R01 from Novus Biologicals
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MISSION® esiRNA - EHU090921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11335 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11335 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00325 from Sigma-Aldrich
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KNG1 siRNA (Human) - CRH2593 from Cohesion Biosciences
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shRNA set against Human KNG1 (NM_000893.3) - SHH326955 from Creative biogene
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KNG1 shRNA Plasmid (Human) - CHH2593 from Cohesion Biosciences
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KNG1 miRNA 3'UTR clone - MiUTR3H-12400 from Creative biogene
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KNG1 miRNA 3'UTR clone - MiUTR3H-12401 from Creative biogene
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