TDP2

Gene Symbol	TDP2
Entrez Gene	51567
Alt Symbol	AD022, EAP2, EAPII, TTRAP, dJ30M3.3, hTDP2
Species	Human
Gene Type	protein-coding
Description	tyrosyl-DNA phosphodiesterase 2
Other Description	5'-Tyr-DNA phosphodiesterase|5'-tyrosyl-DNA phosphodiesterase|ETS1-associated protein 2|ETS1-associated protein II|TRAF and TNF receptor associated protein|TRAF and TNF receptor-associated protein|VPg unlinkase|tyr-DNA phosphodiesterase 2|tyrosyl-RNA phosphodiesterase
Swissprots	Q2TBE2 Q5JYM0 O95551 B4DKL8 B4DQ95 Q9NYY9 Q7Z6U5 Q9NUK5
Accessions	AAT09764 EAW55458 EAW55459 O95551 AF201687 AAG35600 AF223469 AAF64144 AJ269473 CAB92966 AJ420495 AK002168 BAA92119 AK296623 BAG59230 AK298699 BAG60857 AK308836 BC017553 AAH17553 BC110375 AAI10376 EU446614 ABZ92143 JN104587 AFK13123 XR_926244 NM_016614 NP_057698
Function	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'- tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'- tyrosyl-DNA phosphodiesterase in cells. Also acts as a 5'-tyrosyl- RNA phosphodiesterase following picornavirus infection: its activi
Subcellular Location	Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10764746}.

• Antibodies
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ETS1 associated protein II full length protein - ab135019 from Abcam Category Protein Prices $528.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human ETS1 associated protein II full length protein - ab140722 from Abcam Category Protein Source E. coli Species Human

TDP2 / TTRAP Antibody Blocking Peptide - LS-E855 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ETS1 associated protein II Recombinant Protein - H00051567-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ETS1 associated protein II Recombinant Protein - H00051567-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ETS1 associated protein II Partial Recombinant Protein - H00051567-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ETS1 associated protein II Blocking Peptide - NBP2-11491PEP from Novus Biologicals Category Protein Prices $249.00 Sizes 250 µg Species Human

Recombinant Human ETS1 associated protein II Protein - NBP2-22913 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

EAPII-Antibody-C-term-Blocking-peptide - BP11233b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TDP2 protein - orb191405 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source Escherichia Coli. Species Human

TDP2 protein (His tag) - 80R-2728 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

TTRAP (1-362, His-tag) - AR50848PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

TTRAP (1-362, His-tag) - AR50848PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

TTRAP - H00051567-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TTRAP - H00051567-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TTRAP - H00051567-P02 from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Species Human

TTRAP - H00051567-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TTRAP - H00051567-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TTRAP - H00051567-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TTRAP - H00051567-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TDP2, 1-362aa, Human, His tag, E.coli - 01-P2024 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

TTRAP fusion protein - Ag2846 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TTRAP fusion protein - Ag8283 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TDP2, Active Human Recombinant Protein - GWB-PSAAD3 from Genway Biotech Category Protein Prices $600.00 Sizes 10 µg Species Human

Recombinant Human TDP2, His-tagged - TDP2-7580H from Creative Biomart Category Protein Source E. coli Species Human

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