| Gene Symbol |
GRPEL2
|
| Entrez Gene |
134266
|
| Alt Symbol |
Mt-GrpE#2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GrpE-like 2, mitochondrial (E. coli)
|
| Other Description |
grpE protein homolog 2, mitochondrial
|
| Swissprots |
Q8TAA5 B4DFA6 Q49AJ6
|
| Accessions |
EAW61786 Q8TAA5 AK074293 BAB85040 AK091237 AK096445 AK294005 BAG57367 AL704536 AL832325 CAD38619 BC036678 AAH36678 BC070090 AAH70090 HQ447481 ADQ31967 NM_152407 NP_689620
|
| Function |
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000250}.
|
