| Gene Symbol | HLA-DRB4 |
|---|---|
| Entrez Gene | 3126 |
| Alt Symbol | DR-4, DR4, DRB4, HLA-DR4B |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class II, DR beta 4 |
| Other Description | DRB1 transplantation antigen|HLA class II histocompatibility antigen, DR beta 4 chain|MHC HLA DR-beta chain|MHC class II antigen DRB4|MHC class II antigen HLA-DR-beta|MHC class2 antigen|human leucocyte antigen DRB4|leukocyte antigen |
| Swissprots | Q8WLT9 B0S863 P79664 Q860N4 Q29889 Q6TLK6 O78042 Q30163 P13762 Q861F3 Q9BS54 |
| Accessions | AAA03144 AAA03486 AAA17991 AAA52320 AAA52323 AAA52327 AAA52769 AAA59691 AAA59802 AAA59815 AAA59830 AAA62839 AAA62840 AAA72782 AAA86243 AAA86244 AAA91843 AAA99536 AAB18636 AAB52230 AAB63532 AAB94612 AAC05578 AAC37561 AAC51629 AAC51630 AAD09441 AAD31292 AAD53054 AAD53910 AAF32284 AAF61218 AAF65493 AAF65496 AAG22593 AAG22826 AAK20875 AAK27712 AAK55114 AAK81687 AAN52494 AAO20088 AAO20089 AAQ18120 AAQ18913 AAQ96922 AAR07616 AAR28666 AAU88021 AAV33680 AAV33681 AAV33682 AAV33683 AAV38108 AAV38129 AAW59561 AAW82078 AAY40254 AAZ67361 ABA06596 ABC84557 ABQ08747 AJA90823 BAA09461 BAA10907 BAA13097 BAA13098 BAA14036 BAA14037 BAB16298 BAC75547 BAD02942 BAD91204 BAI60043 BAO73168 BAO73169 BAO73170 BAO73171 CAA11127 CAA46536 CAA68150 CAA68195 CAA70497 CAB65073 CAB65103 CAB65735 CAB96577 CAC00534 CAC19015 CAC20415 CAC27124 CAC28260 CAH23708 CAI35044 CAJ30431 CAJ33581 CAR57840 CBL95103 P13760 P13762 AF017439 AAB70553 AF048707 AAC31951 AF361548 AAM00252 AF361549 AAM00253 AI829825 AK225683 AK225690 AK291499 BAF84188 AK292151 BAF84840 AK293020 BAF85709 AY961064 AAX63452 AY961067 AAX63455 AY961070 AAX63458 BC005312 AAH05312 BF974249 DQ284431 ABC66198 DQ284433 ABC66200 GQ891550 ACX50637 M14190 AAA36288 M15071 AAA59813 M15178 AAA35995 M15179 M16732 AAA59825 M16942 AAA36296 M17385 AAA36300 M17388 AAA36299 M30180 AAA59714 M59803 AAA64237 S48645 AAB24005 U17379 AAC50165 U29342 AAB63410 U35375 AAA75373 U35729 AAA79144 U37433 AAB63411 U47028 AAB63412 U70543 U70544 XM_011547880 XP_011546182 XM_011547881 XP_011546183 XM_011548127 XP_011546429 XM_011548128 XP_011546430 XM_011548129 XP_011546431 XM_011548130 XP_011546432 XM_011548427 XP_011546729 XM_011548428 XP_011546730 XM_011548429 XP_011546731 XR_247369 XR_952975 XR_953079 NM_021983 NP_068818 |
| Function | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Top Pathways | Leishmaniasis, Influenza A, HTLV-I infection, Tuberculosis, Herpes simplex infection |