| Gene Symbol |
CRB3
|
| Entrez Gene |
92359
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
crumbs family member 3
|
| Other Description |
crumbs homolog 3|crumbs protein homolog 3|protein crumbs homolog 3
|
| Swissprots |
Q8N0V8 Q8WVA0 A8KA91 Q9BUF7 D6W643
|
| Accessions |
EAW69083 EAW69084 EAW69085 EAW69086 Q9BUF7 AF503290 AAM23013 AK000653 AK292956 BAF85645 AY103469 AAM44074 AY358684 AAQ89047 BC002652 AAH02652 BC018409 AAH18409 BM129809 CN403242 XM_005259680 XP_005259737 NM_139161 NP_631900 NM_174881 NP_777377
|
| Function |
Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. {ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572}.
|
| Subcellular Location |
Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.
|
| Tissue Specificity |
Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate. {ECO:0000269|PubMed:12527193, ECO:0000269|PubMed:14718572}.
|
| Top Pathways |
Tight junction
|
![Western Blot: CRB3 Overexpression Lysate (Adult Normal) [NBP2-05070] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CRB3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5367_CRB3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05070-img0001.jpg)