| Gene Symbol |
AHR
|
| Entrez Gene |
196
|
| Alt Symbol |
bHLHe76
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aryl hydrocarbon receptor
|
| Other Description |
AH-receptor|ah receptor|aromatic hydrocarbon receptor|class E basic helix-loop-helix protein 76
|
| Swissprots |
Q13803 Q13728 A4D130 Q13804 P35869
|
| Accessions |
AAA92082 AAA92083 AAA92084 BAA07235 CCO13674 EAL24281 EAW93686 EAW93687 P35869 AA329775 AK130815 AK307495 BC021696 BC069390 AAH69390 BC070080 AAH70080 BQ020427 BQ024331 BX505160 D16354 BAA03857 L19872 AAA16210 NM_001621 NP_001612
|
| Function |
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. {ECO:0000269|PubMed:10395741, ECO:0000269|PubMed:7961644}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
|
| Tissue Specificity |
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. {ECO:0000269|PubMed:7515333, ECO:0000269|PubMed:8246913}.
|
![Western Blot: AHR Overexpression Lysate (Denatured) [H00000196-T01] - Lane 1: AHR transfected lysate (96.1 KDa) Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/29334_AHR-Overexpression-Lysate-(Denatured)-Western-Blot-H00000196-T01-img0004.jpg)
![Western Blot: Aryl hydrocarbon Receptor Overexpression Lysate (Adult Normal) [NBL1-07403] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Aryl hydrocarbon Receptor.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/7300_Aryl%2520hydrocarbon%2520Receptor%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07403-img0002.jpg)