| Gene Symbol | birc5.2-a |
|---|---|
| Entrez Gene | 735055 |
| Alt Symbol | SIX, Su1, svv2, xSurvivin2 |
| Species | Xenopus |
| Gene Type | protein-coding |
| Description | baculoviral IAP repeat containing 5 |
| Other Description | baculoviral IAP repeat-containing 5, gene 2 |
| Swissprots | Q50L39 Q5XGX1 |
| Accessions | BC089271 AAH89271 NM_001096515 NP_001089984 |
| Function | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Does not appear to exhibit anti-apoptotic activity. Plays a role in increasing blood vessel size during development. {ECO:0000250|UniProtKB:Q804H7, ECO:0000269|PubMed:15853809, ECO:0000269|PubMed:16759290}. |
| Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:O15392}. Nucleus {ECO:0000250|UniProtKB:O15392}. Chromosome, centromere {ECO:0000250|UniProtKB:O15392}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. {ECO:0000250|UniProtKB:O15392}. |
| Tissue Specificity | Highly expressed in vascular endothelial cells of tadpoles. {ECO:0000269|PubMed:16759290}. |