| Gene Symbol |
Aox1
|
| Entrez Gene |
54349
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
aldehyde oxidase 1
|
| Other Description |
aldehyde oxidase (female form)|azaheterocycle hydroxylase 1
|
| Swissprots |
Q9Z0U5 Q9R240
|
| Accessions |
EDL99010 Q9Z0U5 AF110477 AAD16999 AF110478 AAD17000 XR_594396 NM_019363 NP_062236
|
| Function |
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6- deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. Is a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also catalyzes nitric oxide (NO) production; under anaerobic conditions, reduces nitrite to NO with NADH or aldehyde as electron donor, but under aerobic conditions, NADH is the preferred substrate. These reactions may be catalyzed by several isozymes. May play a role in adipogenesis. {ECO:0000269|PubMed:17353002, ECO:0000269|P
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17353002}.
|
| Tissue Specificity |
Expression in liver (at protein level). Also detected in heart, lung, spleen and kidney. {ECO:0000269|PubMed:17353002, ECO:0000269|PubMed:9920943}.
|
| Top Pathways |
Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism
|