CENPE

Gene Symbol	CENPE
Entrez Gene	1062
Alt Symbol	CENP-E, KIF10, MCPH13, PPP1R61
Species	Human
Gene Type	protein-coding
Description	centromere protein E, 312kDa
Other Description	Centromere autoantigen E (312kD)|centromere-associated protein E|kinesin family member 10|kinesin-related protein CENPE|protein phosphatase 1, regulatory subunit 61
Swissprots	A6NKY9 Q02224 A8K2U7 Q4LE75
Accessions	CBX47458 EAX06169 EAX06170 EAX06171 Q02224 AA210728 AA210858 AB209996 BAE06078 AK290362 BAF83051 AL596934 AU100312 AW499901 AY429526 BC156501 AAI56502 BQ231878 BQ434767 BQ447425 CD644410 CN418651 Z15005 CAA78727 XM_011531544 XP_011529846 XM_011531545 XP_011529847 XM_011531546 XP_011529848 XM_011531547 XP_011529849 XM_011531548 XP_011529850 XM_011531549 XP_011529851 NM_001286734 NP_001273663 NM_001813 NP_001804
Function	Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle. {ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:7889940}.
Subcellular Location	Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CENP-E (C-5) - sc-376685 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CENP-E (C-19) - sc-11291 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CENP-E (H-300) - sc-22790 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CENP-E (mAb177) - sc-47745 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CENP-E (S-20) - sc-30941 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CENP-E (P-15) - sc-30942 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CENP-E (V-20) - sc-30940 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CENPE antibody - ab4163 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CENPE antibody [1H12] - ab5093 from Abcam Prices $401.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1H12

Anti-CENPE antibody [EPR4542(2)] - ab133583 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4542(2)

Anti-CENPE antibody [EPR4543(2)] - ab124733 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4543(2)

Anti-CENPE Antibody (C-Terminus) - LS-C54644 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-CENPE Antibody (aa2572-2602, APC) - LS-C254615 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CENPE Antibody (aa2572-2602, FITC) - LS-C254616 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CENPE Antibody (clone 1H12) - LS-C59522 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1H12

Anti-CENPE Antibody (clone CENP-E.1H12) - LS-C137476 from LifeSpan Bioscience Prices $315.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone CENP-E.1H12

Anti-CENPE Antibody (aa2572-2602, Biotin) - LS-C254617 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CENPE Antibody (Internal, clone EPR4543(2)) - LS-C138795 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4543(2)

Anti-CENPE Antibody (aa2572-2602, Azide-free, HRP) - LS-C254618 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CENPE Antibody (aa2572-2602, PE) - LS-C254619 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CENPE Antibody (aa2050-2100) - LS-C288709 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CENPE Antibody (aa2572-2602) - LS-C159333 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CENPE Antibody (clone 1H12) - LS-C82256 from LifeSpan Bioscience Prices $380.00 Sizes 50 µl Host Mouse Clonality Monoclonal Clone 1H12

Anti-CENPE Antibody (aa2500-2550) - LS-C288714 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CENPE Antibody (aa2450-2590, Biotin) - LS-C297625 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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