CENPE

Gene Symbol	CENPE
Entrez Gene	1062
Alt Symbol	CENP-E, KIF10, MCPH13, PPP1R61
Species	Human
Gene Type	protein-coding
Description	centromere protein E, 312kDa
Other Description	Centromere autoantigen E (312kD)|centromere-associated protein E|kinesin family member 10|kinesin-related protein CENPE|protein phosphatase 1, regulatory subunit 61
Swissprots	A6NKY9 Q02224 A8K2U7 Q4LE75
Accessions	CBX47458 EAX06169 EAX06170 EAX06171 Q02224 AA210728 AA210858 AB209996 BAE06078 AK290362 BAF83051 AL596934 AU100312 AW499901 AY429526 BC156501 AAI56502 BQ231878 BQ434767 BQ447425 CD644410 CN418651 Z15005 CAA78727 XM_011531544 XP_011529846 XM_011531545 XP_011529847 XM_011531546 XP_011529848 XM_011531547 XP_011529849 XM_011531548 XP_011529850 XM_011531549 XP_011529851 NM_001286734 NP_001273663 NM_001813 NP_001804
Function	Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle. {ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:7889940}.
Subcellular Location	Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CENPE ELISA Kit (Sandwich ELISA) - LS-F9279 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.124 ng/ml Range 0.313-20 ng/ml

Centromere Protein E, CENPE, Human, ELISA Kit - E-EL-H0688 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Centromere Protein E (CENPE), Human, ELISA Kit - SEA276Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.124ng/mL Range 0.312-20ng/mL

Centromere Protein E, CENPE, Mouse, ELISA Kit - E-EL-M0258 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Centromere Protein E, CENPE, Rat, ELISA Kit - E-EL-R0179 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Centromere Protein E, CENPE, Rabbit, ELISA Kit - E-EL-RB1131 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Centromere Protein E, CENPE, Chicken, ELISA Kit - E-EL-Ch1405 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Centromere Protein E, CENPE, Porcine, ELISA Kit - E-EL-P1479 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Centromere Protein E, CENPE, Guinea Pig, ELISA Kit - E-EL-GP0278 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Centromere Protein E, CENPE, Monkey, ELISA Kit - E-EL-MK0675 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human CENPE ELISA Kit - HC0655 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CENPE ELISA Kit - AC0655 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

ELISA Kit for Centromere Protein E (CENPE) - SEA276Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.124ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human CENPE(Centromere Protein E) ELISA Kit - E-EL-H0688 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

CENPE, ELISA Kit - MBS2511118 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CENPE, ELISA Kit - MBS2502176 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CENPE, ELISA Kit - MBS2503484 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CENPE, ELISA Kit - MBS2511435 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CENPE, ELISA Kit - MBS2511727 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CENPE, ELISA Kit - MBS2503578 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CENPE, ELISA Kit - MBS2507179 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

CENPE, ELISA Kit - MBS2515416 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Centromere Protein E, ELISA Kit - MBS721666 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere Protein E, ELISA Kit - MBS745991 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Centromere Protein E, ELISA Kit - MBS029459 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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