CENPE

Gene Symbol	CENPE
Entrez Gene	1062
Alt Symbol	CENP-E, KIF10, MCPH13, PPP1R61
Species	Human
Gene Type	protein-coding
Description	centromere protein E, 312kDa
Other Description	Centromere autoantigen E (312kD)|centromere-associated protein E|kinesin family member 10|kinesin-related protein CENPE|protein phosphatase 1, regulatory subunit 61
Swissprots	A6NKY9 Q02224 A8K2U7 Q4LE75
Accessions	CBX47458 EAX06169 EAX06170 EAX06171 Q02224 AA210728 AA210858 AB209996 BAE06078 AK290362 BAF83051 AL596934 AU100312 AW499901 AY429526 BC156501 AAI56502 BQ231878 BQ434767 BQ447425 CD644410 CN418651 Z15005 CAA78727 XM_011531544 XP_011529846 XM_011531545 XP_011529847 XM_011531546 XP_011529848 XM_011531547 XP_011529849 XM_011531548 XP_011529850 XM_011531549 XP_011529851 NM_001286734 NP_001273663 NM_001813 NP_001804
Function	Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle. {ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:7889940}.
Subcellular Location	Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CENPE peptide - ab45476 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CENPE peptide - ab24674 from Abcam Category Peptide

Human CENPE protein fragment - ab158097 from Abcam Category Protein Source Wheat germ Species Human

CENPE Antibody Blocking Peptide - LS-E5471 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CENPE Antibody Blocking Peptide - LS-E25424 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CENPE Protein - H00001062-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CENPE-Antibody-C-term-Blocking-Peptide - BP17985b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CENPE blocking peptide - GTX89617-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

Goat anti CENPE antibody Immunizing peptide - orb17711 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human Centromere Protein E Protein - abx065849 from Abbexa Category Protein Source E.coli Species Human

CENPE Peptide - AC21-0252-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CENPE - H00001062-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CENPE - H00001062-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Centromere Protein E Peptide - 45-392P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

Recombinant Centromere Protein E (CENPE) - RPA276Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Centromere Protein E (CENPE) - RPA276Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Centromere Protein E (CENPE) - RPA276Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Centromere-associated protein E(CENPE) ,partial - CSB-YP005209HU CSB-EP005209HU CSB-BP005209HU CSB-MP005209HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Centromere Protein E (CENPE), Recombinant Protein - MBS2018455 from MyBioSource Category Protein Prices $190.00, $395.00, $610.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Centromere-associated protein E (CENPE), partial, Recombinant Protein - MBS957306 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Centromere protein E, Peptide - MBS425060 from MyBioSource Category Protein Prices $175.00 Sizes 100 µg Species Human, Rat, Dog, Bovine

CENPE Recombinant Protein Antigen - NBP1-82875PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CENP-E antibody ( mAb ) , 200 ug - HM-AB1143 from Novatein Biosciences Prices $442.00 Sizes 200 µg

CENP-E antibody ( mAb ) , 10 ug - HM-AB1144 from Novatein Biosciences Prices $91.00 Sizes 10 µg

CENPE Peptide, Human - M34GP02966H from Creative Peptides Category Peptide Source Synthetic. Species Human

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