RAB1B
| Gene Symbol | RAB1B |
|---|---|
| Entrez Gene | 81876 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB1B, member RAS oncogene family |
| Other Description | ras-related protein Rab-1B|small GTP-binding protein |
| Swissprots | Q9H0U4 A8K7S1 |
| Accessions | Q9H0U4 AF092437 AAP97212 AJ245875 CAC21570 AK292086 BAF84775 AK315333 BAG37733 AL136635 CAB66570 AM393195 CAL38073 BC028331 BC071169 AAH71169 BG717501 CR533462 CAG38493 U66621 AAC51196 NM_030981 NP_112243 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. {ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:9437002}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11389151}. Membrane {ECO:0000269|PubMed:11389151}; Lipid-anchor {ECO:0000269|PubMed:11389151}; Cytoplasmic side {ECO:0000269|PubMed:11389151}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20545908}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). {ECO:0000250}. |
| Top Pathways | Legionellosis |
Rab 1B CRISPR/Cas9 KO Plasmid (h) - sc-402021 from Santa Cruz Biotechnology
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Rab 1B HDR Plasmid (h) - sc-402021-HDR from Santa Cruz Biotechnology
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Rab 1B Double Nickase Plasmid (h) - sc-402021-NIC from Santa Cruz Biotechnology
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Rab 1B Double Nickase Plasmid (h2) - sc-402021-NIC-2 from Santa Cruz Biotechnology
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Rab 1B CRISPR Activation Plasmid (h) - sc-402021-ACT from Santa Cruz Biotechnology
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Rab 1B CRISPR Activation Plasmid (h2) - sc-402021-ACT-2 from Santa Cruz Biotechnology
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Rab 1B Lentiviral Activation Particles (h) - sc-402021-LAC from Santa Cruz Biotechnology
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Rab 1B Lentiviral Activation Particles (h2) - sc-402021-LAC-2 from Santa Cruz Biotechnology
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Rab 1B siRNA (h) - sc-37155 from Santa Cruz Biotechnology
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Rab 1B shRNA Plasmid (h) - sc-37155-SH from Santa Cruz Biotechnology
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Rab 1B shRNA (h) Lentiviral Particles - sc-37155-V from Santa Cruz Biotechnology
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RAB1B RNAi - H00081876-R01 from Novus Biologicals
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MISSION® esiRNA - EHU089451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17817 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17817 from Sigma-Aldrich
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RAB1B siRNA (Human) - CRJ3076 from Cohesion Biosciences
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RAB1B - MBS8234606 from MyBioSource
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shRNA set against Human RAB1B (NM_030981.2) - SHH387988 from Creative biogene
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shRNA set against Human RAB1B(NM_030981.2) - SHR158052 from Creative biogene
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RAB1B shRNA Plasmid (Human) - CHJ3076 from Cohesion Biosciences
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RAB1B miRNA 3'UTR clone - MiUTR1H-08544 from Creative biogene
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