| Gene Symbol | Mas1 |
|---|---|
| Entrez Gene | 17171 |
| Alt Symbol | Mas-1, Mgra |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | MAS1 oncogene |
| Other Description | MAS proto-oncogene|Mas-related G protein-coupled receptor a|angiotensin-(1-7) receptor|proto-oncogene Mas |
| Swissprots | O35944 Q8BHI8 P30554 |
| Accessions | CAA47964 CDG86213 EDL02043 EDL02044 P30554 AK015036 BAB29684 AK030261 BAC26865 AK030265 BAC26868 BB262893 BC120790 AAI20791 BC125537 AAI25538 BC144900 AAI44901 U96273 AAB69120 XM_006523293 XP_006523356 XM_006523294 XP_006523357 XM_006523296 XP_006523359 XM_006523297 XP_006523360 XM_006523299 XP_006523362 XM_011246190 XP_011244492 XM_011246191 XP_011244493 XM_011246192 XP_011244494 XM_011246193 XP_011244495 XM_011246194 XP_011244496 NM_008552 NP_032578 |
| Function | Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity). Receptor for angiotensin 1-7. {ECO:0000250, ECO:0000269|PubMed:12829792}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Top Pathways | Renin-angiotensin system, Neuroactive ligand-receptor interaction |